Chapter 15&16 Quiz 1

Question 1

Avery el al showed in 1944 that the transformation material——

A. Could be degraded by trypsin
B. Consists of capsular polysaccharide
C. Encode e-lactamase, conferring amplification resistance
D. Is sensitive to deoxyribonuclease
E. Cause dominance of orange over black fur color in the calico cat.

Answer 1

Is sensitive to deoxyribonuclease

Question 2

Down Syndrome most often arises from what ?

A. large chromosomal deletion
B. crossing over during second division of mitosis.
C. fertilization of egg by two sperm (dispermy)
D. mutation caused by carcinogens in tobacco smoke.
E. meiotic nondijunction

Answer 2

meiotic nondijunction

Question 3

The bacteriostaic antibiotic listed below is ?

A. ampicillin
B. ddC
C. kanamycin
D. tamiflu
E.paxlovid

Answer 3

kanamycin

Question 4

Chargaff found the frequency of G in B. subtilis DNA to be around 33%. We would therefore expect the frequency of T to be around ?

A. 25%
B.66%
C.17%
D. 50%
E. 33%

Answer 4

17%

Question 5

Which of the following is NOT a characteristic or example of X-chromosome inactivation ?

A. random
B. clonal
C. barr body
D. maternal transmission of mitochondrial genome
E. early in embryogenesis

Answer 5

maternal transmission of mitochondrial genome

Question 6

Which chromosomal complement would be a NONVIABLE chromosomal aneuploidy ?

A. 47 (XXY)
B. 45 (Y)
C. 45 (14,14/21,21)
D. 47 (21,21,21)
E. 45 (X)

Answer 6

45 (Y)

Question 6

Transformation first studied by Griffth and later by Avery et al relied on …. ?

A. methylation of Cs in GpC islands
B. prion diseased such as bovine spongiform encephalopathy .
C. targeted proteolysis of non-histone protein
D. avirulence of R pneumococcal bacteria strains
E. paternal inheriance of mitochondtrial genome.

Answer 6

avirulence of R pneumococcal bacteria strains

Question 7

A man and woman with normal color vison have a colorblind son; we may conclude that ?

A. the son inherited his father’s mitochondrial genome

B. the father had methyl C on his GpC island

C. the mother was unaffected carrier of the colorblindness allele

D. the father had a somatic cell mutaion

E. the mother had a deletion of the XIST gene

Answer 7

the mother was unaffected carrier of the colorblindness allele

Question 8

The mitochondrial genome is maternally transmitted because

A. genes on the X chromosome are domiant and genes on the Y chromosome are recessive

B. Recombination is more frequent during spermatogenesis than during oogenesis

C. mitochondrial genes recombine during interkinesis between the meiotic divisions

D. the sperm head has no mitochnodria

Answer 8

the sperm head has no mitochnodria

Question 9

A female heterozygous for an X-link gene, what terms is it ?

Answer 9

Mosaic

Question 9

Always uses homozygous recessive for every gene examined , what terms to respond that ?

Answer 9

Test cross

Question 10

Aneuploidy
(非整倍体)

Answer 10

Single chromosome

Question 11

Monosomic
(单体)

Answer 11

Only copy of particular chromosome [e.g. 45 (X) ]

Question 11

Trisomic (三体性)

Answer 11

Three copy of a particular chromosome [.g 47(XXY) ]

Question 12

Polyploidy (多倍体)

Answer 12

An aneuploidy of the entire chromosomal ( 整个染色体的非整倍性)

Question 13

！State the three biophysical values that can most readily be determined from Rosalind Franklin’s diffraction patterns.

Answer 13

distances between base one 0.34 nm

distances between the DNA helix is 2 nm

distances between the fuist,,,,, a DNA is 3.4 nm. these were

Question 14

What does “Griffith” do in 1928 ?

Answer 14

he doing two strains of the baterium, pathogenic and harmless

R can tranformed to S