Chpt 3 (Spleen Clinical Aspects)

Question 1

Splenectomy: Effects of (3)

Answer 1

1. Blood changes
   (increase in number of platelets and abnormal RBCs)
2. Infection
   Increased risk of bacterial septicemia
   Especially in children with strep pneumo
3. Liver (some in bone marrow too) takes of blood filtration
   Starts in ~2 hrs and fully functioning in ~24 hrs
   Macrophage numbers increase greatly

Question 2

Infectious mono - EBV

How does it spread through our body?

Answer 2

1. Replicates in nasopharyngeal epithelium
2. Can spread to salivary glands, lymph nodes and oropharyngeal lymphoid tissues
3. Then to liver, spleen, B cells, and blood

Question 3

______________ cells are primary source of new virus (EBV)

Answer 3

Epithelial cells

Question 4

EBV

B cells become infected as they circulate through __________________, which initiates a ________________________,
causing a decrease in __________________.

Answer 4

Oropharynx
Cytotoxic T cell response
B cell numbers

Question 5

Classic mono symptoms appear ____________ weeks after exposure.

Symptoms include:

Answer 5

4-7

Sore throat, fever, swollen lymph nodes

–also chills, nausia, vomiting, headache, joint pain, enlarged spleen, jaundice, skin rash