Chpt 3 (Spleen)

Question 1

5 functions

Answer 1

1. Immunity
2. Blood filtration
3. Long term T lymphocyte storage
4. Stores some WBC’s and platelets (lots of monocytes)
5. Hemopoietic organ in fetus

Question 2

Hemopoietic organ in fetus

Answer 2

Spleen

Question 3

Spleen stores:

Answer 3

T lymphocytes long term
WBC’s - lots of monocytes
Platelets

Question 4

Capsule made of

Answer 4

Thick dense irregular fibroelastic CT

–also some smooth ms cells and or myofibroblasts

Question 5

Trabeculae made of

Answer 5

Dense irregular CT

Question 6

Trabeculae is

Answer 6

Thick, numerous, tortuous

Carry blood vessels (trabecular arteries)

Question 7

Lymphatic vessels (afferent vs efferent)

Answer 7

No afferents

Efferents do arise

Question 8

Role of reticular fibers in spleen

Fibers produced by

Answer 8

Support spleen cells

Produced by reticular cells

Question 9

Tell me about White Pulp

Answer 9

White like WBCs!!

5-20% of spleen

Stained purple on pix

Question 10

Areas of white pulp (3)

Answer 10

1. Next to the capsule and septa***
2. Splenic nodules
3. Periarteriolar lymphoid sheaths = PALS

Question 11

Tell me about Splenic Nodules

Answer 11

• Areas of white pulp
• Primarily B cell structures
• More common in children
• Humoral immunity

Question 12

Tell me about PALS

Answer 12

• Periarteriolar Lymphoid sheaths
• Long term storage for T cells
• Primarily a T cell structure
• Surround central arterioles (usually surround a clear while circle)
• Cell-mediated immunity

Question 13

Red pulp: Areas that are not ____________________

Answer 13

White pulp or CT

Question 14

Red pulp functions (2)

Answer 14

1. Rapid blood filtration

2. Allows contact with blood-borne foreign antigens

Question 15

Regarding Red pulp structure

Fenestrated venous sinuses made of _____________, which are _________________

Answer 15

Stave cells

Elongated endothelial cells

Question 16

Red pulp circulation is a combination of

Answer 16

Closed and open capillaries

Question 17

In red pulp, closed-capillaries connect to _____________ made of ________________

Is any blood filtered here?

Answer 17

Fenestrated venous sinuses made of stave cells

Yes “some blood is filtered”

Question 18

In red pulp, _____________________ end abruptly

Is any blood filtered here?

Answer 18

Open-capillaries

Yes “all blood enters red pulp to be filtered”

Question 19

Splenic cords are a structural component of red pulp. Components include:

Answer 19

• Loose network of reticular fibers
• reticular cells
• MANY macrophages
• Blood = wbc’s, rbc’s, platelets, many monocytes
• APCs (mostly dendritic cells and macrophages)
• Plasma cells - sometimes many (B cells mature into plasma cells)