chp 18

Question 1

addition of a halogen at alpha carbon

Answer 1

X2 and acid

Question 2

addition of O- (replacing alpha carbon)

Answer 2

X2 and base

Question 3

why is the hydrogens attached on the alpha carbon very acidic?

Answer 3

the hydrogen proton can easily be given off and the negative charge on the C is stabilized through resonance

Question 4

process of alkylation of enolate

Answer 4

NaH = H-
the H- takes an alpha H and creates a carbon anion

the carbon anion attacks the CH2 which makes a halogen leave

Question 5

enamine will ______ in an enolate reactionn

Answer 5

protect the carbonyl

Question 6

protecting group with Si

how do you get rid of it?

Answer 6

(CH3)3Si-Cl

Use F- to take it off

Question 7

LDA is a _____

Answer 7

big bulky base

Question 8

in an aldol reaction the ____ is the attacker

Answer 8

the enolate ion

Question 9

aldol process

Answer 9

1) form an attacker (enolate ion) by deprotonating the alpha carbon with a base
2) attack the carbonyl
3) protonate the negative O
4) deprotonate and form a double bond and push off OH

Question 10

1,2 addition of a nucleophile

Answer 10

1,2 refers to addition of H to the carbonyl and a nucleophile to the carbon 2

Question 11

1,4 addition of a nucleophile

Answer 11

1,4 refers to addition of H to the carbonyl and a nucleophile to the carbon 2

Question 12

in Michael reaction the conjugated is the ______

theres a partial positive charge on the ______ stabilized by resonance

Answer 12

in Michael reaction the conjugated is the acceptor

theres a partial positive charge on the beta carbon stabilized by resonance

Question 13

Micheal reaction ends up with ________ product

Answer 13

1,5 dicarbonyl

Question 14

Robinson annulation

Answer 14

Michael reaction and reacts with itself and closes up as a ring