Choudhury BSC Flashcards
1
Q
what is bilirubin
what carries it
what removes it from circulation
A
end product of heme degradation
carried with albumin
removed by hepatocytes
2
Q
what are the steps in transfer of bilirubin from blood to bile
what is a disease that can occur if the last step fails
A
hepatocellular uptake by hepatocytes
intracellular binding within hepatocytes
conjugation- UDPGT
biliary excretion into bile canaliculi by an ATP dependent transport process by MRP2
-mutations of the MRP2 result in Dubin-Johnson syndrome
3
Q
what is the normal range for serum bilirubin
A
0.2-1.2 mg/dL
