Choroid Flashcards

1
Q

What are the three things that make up the uvea?

A
  • choroid
  • ciliary body
  • iris
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2
Q

The choroid extends from what to what? And lies between what two structures?

A
  • extends from the ora-serrate to the optic nerve

- lies between the sclera and the retina

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3
Q

What is the ora-serrata?

A
  • tapering of the retina and the choroid.
  • the two layers stop at this point and from that point forward is known as the ciliary body.
  • point at which the retinal pigmented epithelium becomes pigmented ciliary epithelium
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4
Q

What does the choroid mostly consist of ?

A

Blood vessels to supply the outer retinal layers

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5
Q

What supplies the inner retinal layers?

A

Central retinal artery

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6
Q

What is the connective tissue between the sclera and the choroid?

A

-suprachoroid

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7
Q

What is the connective tissue between choroid and retina?

A

Bruch’s membrane

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8
Q

What are the layers of the choroid from Superficial (scleral) to deep (retina)?

A
  • suprachoroid lamina
  • choroidal Stroma
  • Choriocapillaris
  • Bruch’s membrane
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9
Q

The suprachoroid lamina is a hybrid zone meaning what?

A

-it contains components from sclera (collagen and fibroblasts) and choroid( melanocytes)

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10
Q

The looseness of the suprachoroid lamina allows for what?

A

-swelling of the vascular net without causing detachment

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11
Q

The suprachoroid also space carries what structures?

A

-carries long posterior ciliary arteries and nerves from posterior to anterior globe

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12
Q

What kind of cells are in the choroidal stroma?

A
  • melanocytes
  • fibroblasts
  • macrophages
  • lymphocytes
  • mast cells
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13
Q

How are the collagen fibrils arranged in the choroidal stroma?

A

-collagen fibrils are arranged circularly around the vessels (branches of short posterior ciliary arteries)

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14
Q

What are the three vessel layers of the choroidal stroma?

A
  • haller’s layer
  • sattler’s layer
  • capillary bed
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15
Q

The deeper you go into the stroma, what happens to the size of the vessels?

A

-the deeper you go, the smaller the vessels get

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16
Q

What is the most superficial layer of vessels in choroidal stroma? Middle? Deepest? Talk about their size too

A
  1. Haller’s layer-largest lumina
  2. Sattler’s layer-middle
  3. Capillary bed-smallest, closest to retina
17
Q

The veins in the stroma are different because of what characteristic? They also join together to exit the choroid as what veins?

A
  • choroidal veins have no valves

- they join to make vortex veins

18
Q

Describe the sympathetic innervation of the choroidal stroma

A
  • vasoconstriction and decreased choroidal blood flow

- comes from sympathetic trunk of carotid plexus via ciliary ganglion

19
Q

Describe the parasympathetic innervation of choroidal stroma

A
  • vasodilation and increased choroidal blood flow

- comes from division of CN III via ciliary ganglion

20
Q

Both parasympathetic and sympathetic systems use what nerves to innervate the choroidal stroma?

A

Short ciliary nerves

21
Q

What is the choriocapillaris layer?

A
  • specialized capillary bed

- single layer of anastomoses, fenestrated capillaries with wide lumina

22
Q

In the choriocapillaris, what direction do most fenestrations face?

A

Face towards the retina

23
Q

Why is the size of the lumen in choriocapillaris important?

A

-it is larger than normal capillaries so blood cells can pass through side by side instead of a single file line like normal capillaries

24
Q

What is the function of pericytes in the choriocapillaris?

A

-contractile function to alter local blood flow

25
Q

Where is the choriocapillaris the densest? Why?

A

In the macular area because it is the sole blood supply for that region of the retina

26
Q

Does the choriocapillaris continue into the ciliary body?

A

Nah

27
Q

What is the course of Bruch’s membrane?

A
  • from optic nerve to ora serrata

- undergoes some modification before continuing into the ciliary body

28
Q

Name the layers of Bruch’s membrane from superficial to deep

A
  • basement membrane of choriocapillaris
  • outer collagenous zone
  • elastic layer
  • inner collagenous zone
  • basement membrane of RPE cells
29
Q

What contributes to the tight adhesion of choroid and outer pigmented layer of the retina?

A

-fine filaments from basement membrane to RPE merge with inner collagenous zone

30
Q

What is the functional/histological change at the ora serrata

A
  • basement membrane of RPE becomes continuous with basement membrane of pigmented epithelium of the ciliary body
  • collagenous and elastic layers of bruch’s membrane disappear into the stroma
  • basement membrane of the choriocapillaris continues as basement membrane of ciliary body capillaries
31
Q

What are the functions of the choroid?

A
  1. Provides nutrient to outer retina and lets catabolites pass from retina to choriocapillaris
  2. Dark pigment absorbs light like the RPE layer
  3. Suprachoroid space lets posterior vessels and nerves go through to supply anterior globe
32
Q

What provides sensory innervation for the uvea?

A

-nasociliary branch off V1

33
Q

What nerve innervates choroidal blood vessels (sympathetic) and what nerve innervates iris dilator and ciliary muscles (sympathetic)

A
  • short posterior ciliary nerves

- long ciliary nerves

34
Q

What ganglion has parasympathetic fibers for the ciliary muscle, iris sphincter, and choroidal vessels?

A

Ciliary ganglion

35
Q

What are drusen?

A

-as we age, excessive basement membrane material is deposited in the collagenous zones (inner) of Bruch’s membrane

36
Q

Where are drusen located? What do they contain? What do they do to the retina?

A
  • contain cellular fragments and an accumulation of basal laminar material
  • located outer to the RPE basement membrane and displace the retina inward