Choriocarcinoma

Question 1

Chiricarcino metastasis to?

Answer 1

tendency to metastasize to the lungs, vagina, CNS, liver, pelvis, GI tract, and kidneys

Question 2

Ssx of choriocarcinoma

Answer 2

Postpartum vaginal bleeding and inadequate uterine regression after delivery

Question 3

U/s of choriocarcinoma shows?

Answer 3

Mass of varying appearance (suggestive of hemorrhage and necrosis)
Hypervascular on color Doppler
Multiple theca lutein cyst

Question 4

Chest X-ray of choriocarcinoma shows

Answer 4

“Cannonball metastases” (hematogenous spread → multiple nodules in the lung)

Question 5

Histology of choriocarcinoma shows

Answer 5

shows anaplastic cytotrophoblasts and syncytiotrophoblasts without chorionic villi

Question 6

Mgt of choriocarcinoma

Answer 6

methotrexate or dactinomycin

Low-risk : monotherapy with methotrexate or actinomycin D

High-risk : multiagent chemotherapy consisting of methotrexate, actinomycin D, etoposide, cyclophosphamide, or vincristine

Surgical treatment (e.g., hysterectomy): may be indicated to stop bleeding from cancerous lesions or to excise distant metastases

Monitor β-HCG levels for at least 12 months.

Question 7

Invasive mole ultrasound shows?

Answer 7

poorly defined uterine mass with potential invasion into the myometrium

Question 8

Invasive mall histology shows

Answer 8

myometrial invasion by abnormal trophoblastic cells with hydropic chorionic villi.