Choosing antibiotics Flashcards
Common side-effects of co-amoxiclav and flucloxacillin?
Cholestatic jaundice
Common side-effects of penicillin?
Hypersensitivity/skin reactions
Common side-effects of clindamycin, cephalosporins and quinolones?
C.difficile colitis
Common side-effects of macrolides
GI disturbances, hepatitis, Q-T interval
Common side-effects of quinolones?
Q-T interval, convulsions, tendonitis
Common side-effects of aminoglycosides/glycopeptides?
Nephrotoxicity/ototoxicity
Common side-effects of vancomycin?
Vancomycin flushing syndrome (red person syndrome).
Common side-effects of trimethroprim?
Hepatotoxicity, staining teeth, photosensitivity, dysphagia
Common side-effects of nitrofurantoin?
Peripheral neuropathy, pulmonary fibrosis
Common side-effects of sulphonamides (co-trimoxazole)?
Stevens-Johnson syndrome, blood dyscrasias
Common side-effects of chloramphenicol?
Aplastic anaemia, grey baby
What are a list of common interactions the antibiotics have with other medications?
Absorption - absorption of tetracyclines & quinolones reduced by antacids/calcium
Broad-spectrum antimicrobials and oral contraceptives - entero-hepatic cycling can lead to contraceptive failure
Broad spectrum antimicrobials and warfarin - increased INR
Metronidazole - disulfiram-like interaction with alcohol
Aminoglycosides/ glycopeptides/ colistin with loop diuretics or ciclosporin or tacrolimus – nephrotoxicity
Quinolones and steroids (tendonitis) or NSAIDs (convulsions)
Macrolides/ quinolones and Q-T prolonging drugs
