Cholinoceptor antagonists Flashcards
Unwanted effects of muscarinic receptor antagonists
Hot as hell-> decreased sweating, thermoregulation
Dry as a bone-> decreased secretions
Blind as a bat-> cycloplegia (ciliary muscle paralysis)
Mad as a hatter-> CNS disturbance
Nicotinic receptor antagonists
-Otherwise known as ganglion blocking drugs
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Hexamethonium
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Trimetaphan
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Effect of nicotinic receptor antagonists
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Hypotension caused by nicotinic receptor antagonists
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alpha-bungarotoxin
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Atropine
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Hyoscine
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Muscarinic receptor antagonists
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Influence of muscarinic receptor antagonists on physiological responses
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Clinical uses of muscarinic receptor antagonists
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Muscarinic receptor antagonists in anaesthetic premedication
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Muscarinic receptor antagonists in motion sickness
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Muscarinic receptor antagonists in Parkinson’s disease
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Muscarinic receptor antagonists in asthma/obstructive airway disease
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Muscarinic receptor antagonists in retina examination
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Muscarinic receptor antagonists in IBS
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Treatment for atropine poisoning
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Botulinum toxin
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Signs and symptoms of atropine poisoning
- headache
- N&V
- dry mouth
- dysphagia (difficulty swallowing)
- blurred vision
- dilated pupils
- hot, dry skin
- dizziness
- drowsiness
- confusion
- anxiety
- seizures
- weak pulse
- irregular heartbeat
Classes of cholinoceptor
- Nicotinic
- Muscarinic
Nicotinic receptors
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Muscarinic receptors
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Affinity
-strength with which the drug binds
Efficacy
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