Cholinergic transmission

Question 1

What are the sites of Acetylcholine action?

Answer 1

• all preganglionic neurons

- post-ganglionic neurons in the parasympathetic system

Question 2

What does the release of Acetylcholine achieve?

Answer 2

Stimulates secretion of adrenaline from the adrenal medulla(no ganglion)

Question 3

Describe the synthesis, storage and release of Ach?

Answer 3

1. ACh leaves the presynaptic vesicle at the synapse.
2. Then AChE-acetylcholinesterase converts ACh into choline.
3. There is a reuptake of choline into the presynaptic terminal.
4. There choline combines with Acetyl CoA to reproduce ACh again.

Question 4

What is the name of the enzyme which converts Acetyl CoA and choline into ACh?

Answer 4

ChAT

Question 5

What is the rate-limiting step in the transmission signalling of Ach?

Answer 5

The conversion of Ach to choline

Question 6

Which receptors work to inhibit further release of Ach?

Answer 6

Presynaptic muscarinic receptors

Question 7

Which receptors work to facilitate further release of ACh?

Answer 7

Presynaptic nicotinic receptors