Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cell Pathology 1 (Pharmacology) - 2016 > Cholinergic Pharmacology > Flashcards

Cholinergic Pharmacology Flashcards

1
Q

The _____ receptor subtype is richly expressed in brain areas involved in cognition.

A. M1

B. M2

C. M3

D. Nn

E. Nm

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The _____ receptor subtype is richly expressed in brain areas involved in appetite, such as the hypothalamus.

A. M1

B. M2

C. M3

D. Nn

E. Nm

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Parasympathetic stimulation via ____________ such as acetylcholine and carbachol functions to contract the pupillary sphincter and ciliary muscles.

A. Muscarinic agonists

B. Muscarinic antagonists

C. Nicotinic agonists

D. Nicotinic antagonists

E. None of these

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the primary effect of M2 receptor activation on the cardiovascular system?

A

Vagal slowing of the heart rate (negative chronotropic effect)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The atrial muscarinic effec that slows the AV node of the heart is called the:

A. negative ionotropic effect

B. negative dromotropic effect

C. negative chronotopic effect

D. None of these

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The _____ receptor subtype increases tracheobronchial secretions when stimulated.

A. M1

B. M2

C. M3

D. Nn

E. Nm

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ACh binds to what two gut receptors in order to contract muscles in the gut during peristalsis?

A

M3 - increases intracellular free calcium

M2 - inhibits cAMP production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

An initial excitatory postsynaptic potential (EPSP) is mediated by the ______ receptor in autonomic ganglia.

A. M1

B. M2

C. M3

D. Nn

E. Nm

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which of the following is used to treat glaucoma?

A. Acetylcholine

B. Carbachol

C. Pilocarpine

D. Methacholine

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which drug is available as ophthalmic surgical aid for slower onset and more sustained miosis?

A

Carbachol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The _________ inhalation challenge is used by some to test for asthma or occupational airway hypersensitivity.

A

Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why is edrophonium a useful diagnostic agent for myasthenia gravis?

A

It is a rapid, reversible cholinesterase inhibitor.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Treatment of organophosphate poisoning is treated with what two drugs?

A
  1. 2-PAM to reactivate enzyme
  2. Atropine to block muscarinic effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

_____________ is effective in reversing effects of antimuscarinic agents used in surgery to induce tachycardia.

A

Neostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

____________ is an antibody-mediated autoimmune disease targeted against the alpha subunit of nicotinic receptors at the neuromuscular junction.

A

Myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which is NOT a naturally occurring alkaloid muscarinic receptor antagonist?

A. Atropine

B. Hycosamine

C. Scopolamine

D. Tropicamide

A

D - Tropicamide is not naturally occuring as it is a synthetic agent with a shorter duration of action than atropine.

17
Q

___________ is a muscarinic receptor antagonist that is commonly prescribed for lung obstructive disease and does not readily cross membranes or the BBB.

A

Ipratropium

18
Q

____________ is preferred by anesthesiologists to reduce secretions in preparation for, or during, surgeries.

A

Glycopyrrolate - it is charged and reduces secretions without accessing the neural receptors.

19
Q

Since Atropine can cause long term paralysis in the eye muscles, shorter acting analogs such as ___________ are used in ophthalmic diagnostics and surgeries.

A

Tropicamide (4-8 hour duration)

20
Q

Which two drugs can be limit the cardiovascular effects of neostigmine when it is used to reverse neuromuscular blockage?

A

Atropine and glycopyrrolate

21
Q

Which muscarinic antagonist is used for motion disorders?

A

Scopolamine patches (or anti-histamines!)

22
Q

Which of the following drugs is the shortest duration neuromuscular blocking agent?

A. Atracurium

B. Succinylcholine

C. Panocuronium

D. All of these are short-duration NMJ blocking agents.

A

B

23
Q

What is the affect of Pancuronium on cardiac muscarinic receptors?

A

Moderate block of M2 receptors

Cell Pathology 1 (Pharmacology) - 2016 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions