Cholinergic Drugs Flashcards

1
Q

What drug type is Acetylcholine

A

direct-acting cholinomimetic

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2
Q

What drug type is Bethanechol

A

direct-acting cholinomimetic

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3
Q

What drug type is Carbachol

A

direct-acting cholinomimetic

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4
Q

What drug type is Cevimeline

A

direct-acting cholinomimetic

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5
Q

What drug type is Methacholine

A

direct-acting cholinomimetic

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6
Q

What drug type is Pilocarpine

A

direct-acting cholinomimetic

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7
Q

What drug type is Varenicline (chantix)

A

direct-acting cholinomimetic

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8
Q

What drug type is Ambenonium

A

cholinesterase inhibitor

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9
Q

What drug type is Donepezil

A

cholinesterase inhibitor

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10
Q

What drug type is Echothiophate

A

cholinesterase inhibitor

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11
Q

What drug type is Edrophonium

A

cholinesterase inhibitor

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12
Q

What drug type is Galantamine

A

cholinesterase inhibitor

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13
Q

What drug type is Neostigmine

A

cholinesterase inhibitor

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14
Q

What drug type is Physostigmine

A

cholinesterase inhibitor

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15
Q

What drug type is Pyridostigmine

A

cholinesterase inhibitor

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16
Q

What drug type is Rivastigmine

A

cholinesterase inhibitor

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17
Q

What drug type is Tacrine

A

cholinesterase inhibitor

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18
Q

What drug type is Pralidoxime

A

cholinesterase regenerator

19
Q

What drug is used for motion sickness

A

scopolamine

antimuscarinic drug

20
Q

What drugs are used for GI disorders

A

atropine
dicyclomine
glycopyrrolate
hyoscyamine

(antimuscarinic drugs)

21
Q

What drugs are used in ophthalmology

A
atropine
cyclopentolate
homatropine
scopolamine
tropicamide

(antimuscarinic drugs)

22
Q

What drugs are used for respiratory disorders (asthma, COPD)

A

ipratropium
tiotropium

(antimuscarinic drugs)

23
Q

What drugs are used for urinary disorders?

A
darifenacin
fesoterodine
oxybutynin
solifenacin
tolterodine
trospium

(antimuscarinic drugs)

24
Q

What drugs are used for cholinergic poisoning

A

atropine (may add pralidoxime)

25
Q

What drugs are used for movement disorders

A
benztropine
biperiden
orphenadrine
procyclidine
trihexyphenidyl

(antimuscarinic drugs)

26
Q

What drugs is Mecamylamine

A

ganglion blocker

27
Q

What GPCR is M1

A

Gq

phospolipase Cā€“> IP3 and DAG

28
Q

What GPCR is M2

A

Gi

inhibit cAMP, activate K+ channels to hyperpolarize

29
Q

What GPCR is M3

A

Gq

30
Q

What GPCR is M4

A

Gi

inhibit cAMP production

31
Q

What GPCR is M5

A

Gq

32
Q

What is the structure of Nn receptors?

A

alpha and beta ion channel

33
Q

Where are Nn receptors

A

postganglionic cell body, dendrites, CNS

34
Q

Where are M1 receptors

A

nerves

35
Q

Where are M2 receptors

A

heart, nerves, smooth muscle

36
Q

Where are M3 receptors

A

glands, smooth muscle, endothelium

37
Q

Where are M4 receptors

A

CNS

38
Q

Where are M5 receptors

A

CNS

39
Q

What cholinergic receptor is dominant in most organs

A

M3

40
Q

What cholinergic receptor predominates the heart

A

M2

41
Q

What receptors are in smooth muscle

A

M2 and M3

42
Q

What metabolizes direct-acting cholinergic drugs?

A

acetylcholinesterase

43
Q

Parasympathetic effect on lungs

A

bronchoconstriction

stimulates bronchial glands

44
Q

Describe minimal and high dose of Ach to M2 receptors in heart

A

minimal: decrease BP (receptive increase HR)
maximal: hypotension, bradycardia, decreased AV conduction velocity