Cholinergic Drugs

Question 1

What drug type is Acetylcholine

Answer 1

direct-acting cholinomimetic

Question 2

What drug type is Bethanechol

Answer 2

direct-acting cholinomimetic

Question 3

What drug type is Carbachol

Answer 3

direct-acting cholinomimetic

Question 4

What drug type is Cevimeline

Answer 4

direct-acting cholinomimetic

Question 5

What drug type is Methacholine

Answer 5

direct-acting cholinomimetic

Question 6

What drug type is Pilocarpine

Answer 6

direct-acting cholinomimetic

Question 7

What drug type is Varenicline (chantix)

Answer 7

direct-acting cholinomimetic

Question 8

What drug type is Ambenonium

Answer 8

cholinesterase inhibitor

Question 9

What drug type is Donepezil

Answer 9

cholinesterase inhibitor

Question 10

What drug type is Echothiophate

Answer 10

cholinesterase inhibitor

Question 11

What drug type is Edrophonium

Answer 11

cholinesterase inhibitor

Question 12

What drug type is Galantamine

Answer 12

cholinesterase inhibitor

Question 13

What drug type is Neostigmine

Answer 13

cholinesterase inhibitor

Question 14

What drug type is Physostigmine

Answer 14

cholinesterase inhibitor

Question 15

What drug type is Pyridostigmine

Answer 15

cholinesterase inhibitor

Question 16

What drug type is Rivastigmine

Answer 16

cholinesterase inhibitor

Question 17

What drug type is Tacrine

Answer 17

cholinesterase inhibitor

Question 18

What drug type is Pralidoxime

Answer 18

cholinesterase regenerator

Question 19

What drug is used for motion sickness

Answer 19

scopolamine

antimuscarinic drug

Question 20

What drugs are used for GI disorders

Answer 20

atropine
dicyclomine
glycopyrrolate
hyoscyamine

(antimuscarinic drugs)

Question 21

What drugs are used in ophthalmology

Answer 21

atropine
cyclopentolate
homatropine
scopolamine
tropicamide

(antimuscarinic drugs)

Question 22

What drugs are used for respiratory disorders (asthma, COPD)

Answer 22

ipratropium
tiotropium

(antimuscarinic drugs)

Question 23

What drugs are used for urinary disorders?

Answer 23

darifenacin
fesoterodine
oxybutynin
solifenacin
tolterodine
trospium

(antimuscarinic drugs)

Question 24

What drugs are used for cholinergic poisoning

Answer 24

atropine (may add pralidoxime)

Question 25

What drugs are used for movement disorders

Answer 25

``` benztropine biperiden orphenadrine procyclidine trihexyphenidyl ``` (antimuscarinic drugs)

Question 26

What drugs is Mecamylamine

Answer 26

ganglion blocker

Question 27

What GPCR is M1

Answer 27

Gq | phospolipase C--> IP3 and DAG

Question 28

What GPCR is M2

Answer 28

Gi | inhibit cAMP, activate K+ channels to hyperpolarize

Question 29

What GPCR is M3

Answer 29

Gq

Question 30

What GPCR is M4

Answer 30

Gi | inhibit cAMP production

Question 31

What GPCR is M5

Answer 31

Gq

Question 32

What is the structure of Nn receptors?

Answer 32

alpha and beta ion channel

Question 33

Where are Nn receptors

Answer 33

postganglionic cell body, dendrites, CNS

Question 34

Where are M1 receptors

Answer 34

nerves

Question 35

Where are M2 receptors

Answer 35

heart, nerves, smooth muscle

Question 36

Where are M3 receptors

Answer 36

glands, smooth muscle, endothelium

Question 37

Where are M4 receptors

Answer 37

CNS

Question 38

Where are M5 receptors

Answer 38

CNS

Question 39

What cholinergic receptor is dominant in most organs

Answer 39

M3

Question 40

What cholinergic receptor predominates the heart

Answer 40

M2

Question 41

What receptors are in smooth muscle

Answer 41

M2 and M3

Question 42

What metabolizes direct-acting cholinergic drugs?

Answer 42

acetylcholinesterase

Question 43

Parasympathetic effect on lungs

Answer 43

bronchoconstriction | stimulates bronchial glands

Question 44

Describe minimal and high dose of Ach to M2 receptors in heart

Answer 44

minimal: decrease BP (receptive increase HR) maximal: hypotension, bradycardia, decreased AV conduction velocity