Cholinergic Drugs

Question 1

Bethanechol

Answer 1

Muscarinic agonist
Used to stimulate bladder

Question 2

Pilocarpine

Answer 2

Muscarinic agonist
Used to treat dry mouth and glaucoma

Question 3

Donepezil

Answer 3

Reversible acetylcholinesterase inhibitor
Treats the symptoms of Alzheimer’s disease

Question 4

Pyridostigmine

Answer 4

Long lasting acetylcholinesterase inhibitor
Used to treat Myasthenia Gravis

Question 5

Neostigmine

Answer 5

Long acting acetylcholinesterase inhibitor
Used to treat Myasthenia Gravis and stimulate bladder/gut

Question 6

Organophosphorus anticholinesterase

Answer 6

Irreversible acetylcholinesterase inhibitor
Used as incesticides

Question 7

Atropine

Answer 7

Used to treat CNS effects of organophosphorus poisoning

Muscarinic antagonist
Treat mydriasis (dilation of pupil), bradycardia (slow heart rate)

Question 8

Pralidoxime

Answer 8

Pull organophosphorus anticholinesterases off active centers
Effective only 1-2 hrs after exposure

Question 9

Succinylcholine

Answer 9

Nicotinic agonist
Used as a muscle relaxant (anesthesia)

Depolarizing Nicotinic blocker
Brief paralysis- use for quick procedures

Question 10

Botulinum toxin

Answer 10

Used as muscle relaxant
Treats blepharospasms (clenching of eyelids), hemifascial spasm, strabismus (poor eye control)

Question 11

Ipratropium

Answer 11

Muscarinic antagonist
Treat COPD (dilate bronchioles)

Question 12

Scopolamine

Answer 12

Muscarinic antagonist
Treat motion sickness and nausea

Question 13

Mivacurium

Answer 13

Competitive nicotinic blocker
Brief time course
Doesn’t cause fasciculation (muscle twitch) unlike succinylcholine

Question 14

D- tubocurarine

Answer 14

Competitive nicotinic blocker
Used as muscle relaxant

Question 15

Pancuronium

Answer 15

Muscle relaxant in surgery

Question 16

Hexamethonium

Answer 16

Competive Nicotinic blocker