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Pharmacology > Cholinergic Antagonists > Flashcards

Cholinergic Antagonists Flashcards

1
Q

Natural Anti-muscarinic drugs

A

Atropine
Scopolamine/Hyoscine

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2
Q

Semi synthetic Anti-muscarinic drugs

A

Tiotropium
Ipratropium
Homatropine
Anisotropine
Atropine meth-nitrate
Hyoscine butyl-bromide

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3
Q

M1 selective Anti-muscarinic drugs

A

Pirenzepine
Telenzepine

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4
Q

M2 selective Anti-muscarinic drugs

A

Tripitamine
Methoctramine

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5
Q

M3 selective Anti-muscarinic drugs

A

Darifenacin
Solifenacin
Oxybutynin
Tolterodine

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6
Q

M4 selective Anti-muscarinic drugs

A

Himbacine

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7
Q

Half life of Atropine?

A

4hrs

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8
Q

Atropine vs Hyoscine
Which is more metabolized?

A

Hyoscine is more completely metabolized and penetrates the BBB better.

50% of Atropine is metabolized in the Liver and the remaining excreted unchanged in the urine.

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9
Q

Symptoms of Anticholinergic toxicity

A

Hyperthermia
Dry skin and mouth
Flushes
Mydriasis with blurred vision
Delirium, Hallucination, Slurred speech, coma
Seizures
Sinus tachycardia (150bpm)

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10
Q

Anti-Nicotinic Drugs

(Competitive/Non depolarizing Ganglion blockers)

A

Hexamethonium
Trimethaphan
Mecamylamine
Pentolinium
Pempidine

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11
Q

Anti-Nicotinic Drugs

(Non competitive/Depolarizing Ganglion blockers)

A

Nicotine (large dose)
Anticholinesterases (large dose)
Organophosphate

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12
Q

First Ganglion blocker to be recognized?

A

Tetraethylammonium (TEA)

(Has short duration of acting)

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13
Q

Anti-Nicotinic Drugs

(Non competitive/Depolarizing NMJ blockers)

A

Succinylcholine/Suxamethonium
Decamethonium

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14
Q

Anti-Nicotinic Drugs

(Competitive/Non-Depolarizing NMJ blockers)

Long Acting (DD-PP)

A

D-Tubocurarine
Doxacurium
Pipecuronium
Pancuronium

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15
Q

Anti-Nicotinic Drugs

(Competitive/Non-Depolarizing NMJ blockers)

Intermediate Acting (RV-CAR)

A

Rocuronium
Vecuronium
Cistracuronium
Atracuronium
Ropacuronium

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16
Q

Anti-Nicotinic Drugs

(Competitive/Non-Depolarizing NMJ blockers)

Short Acting

A

Mivacurium

17
Q

All NMJ blockers are quaternary compounds.

What does this imply?

A

Not absorbed orally but given I.V or I.M
Do not cross BBB

Pharmacology (5 decks)

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