Adrenergics Flashcards
(Direct Acting Adrenergic Agonists)
Non selective alpha
Epi
NEpi
(Direct Acting Adrenergic Agonists)
Selective alpha 1
(Tip: Remember the -zolines)
Methoxamine
Phenylephrine
Mephentermine
Metaraminol
Midodrine
Oxymetazoline
Tetrahydrozoline
Xylometazoline
(Direct Acting Adrenergic Agonists)
Selective alpha 2
Tip: Remember -nidine and Guan-
Clonidine
Apraclonidine
Moxonidine
Brimonidine
Tizanidine
Lofexidine
Guanfacine
Guanabenz
α-methyldopa
dexmedetomidine
Clenbuterol.
(Direct Acting Adrenergic Agonists)
Non Selective Beta
Isoproterenol/Isoprenaline
Epi
NEpi
(Direct Acting Adrenergic Agonists)
Selective Beta 1
Dobutamine
Denopamine
Xamoterol
Prenalterol
(Direct Acting Adrenergic Agonists)
Selective Beta 2
Tip: remember -erol
Albuterol/Salbutamol (since B2 acts on bronchi)
•Short acting
Bitolterol
Fenoterol
Isoetharine
Metaproterenol
Procaterol
Terbutaline
Ritodrine
• Long Acting
Formoterol
Salmeterol
(Direct Acting Adrenergic Agonists)
Selective Beta 3
Tip: remember -egron
Mirabegron
Solabegron
Amibegron
Vibegron
(Indirect Acting Adrenergic Agonists)
Neuronal release
Amphetamine
Tyramine
Methamphetamine
(Indirect Acting Adrenergic Agonists)
Re-uptake inhibitors
Cocaine
Tricyclic Antidepressants
Atomoxetine
(Indirect Acting Adrenergic Agonists)
MAO inhibitors
Phenelzine
Tranylcypromine
Selegiline
(Indirect Acting Adrenergic Agonists)
COMPT inhibitors
Entacapone
Tolcapone
Alpha 1 Agonist
Prominent Pharmacological Action (PPA)
Vasoconstriction
Alpha 1 Agonist
Principal Therapeutic Uses (PTUs)
Pressor agents
(Rx of hypotension & shock – methoxamine & phenylephrine),
Nasal decongestants (oxymetazoline, tetrahydrozoline, xylometazoline, naphazoline & some preparations of phenylephrine).
Alpha 1 Agonists
Adverse Effects (AEs)
Hypertension, headache, reflex bradycardia, excitability, restlessness, dry mouth, sedation & rebound hypertension ff. abrupt withdrawal.