Cholinergic/Androgenic Drugs (By Class)

Question 1

Muscarinic Agonist

Answer 1

Use: Ileus (postoperative), Urinary retention

AEs:
GI: diarrhea, Abdominal cramps, N/V
Urinary Urgency
Vision Problems

CIs:
Asthma/COPD
Urinary/GI tract obstruction

Notes:

Question 2

Cholinesterase Inhibitor (anti-ChEs)

Answer 2

Use:
Glaucoma
mAChR antagonist toxicity
Myasthenia gravis

AEs:
GI: diarrhea, Abdominal cramps, N/V

CIs:
Asthma/COPD
Urinary/GI tract obstruction

Notes:
Toxicity: DUMMBBELLSS (XS M2/M3 effects)
TX: Atropine (mAChR antagonist), AChE reactivator)

Question 3

Ganglionic Blocker

Answer 3

AKA: Nn Selective Nicotinic Antagonists/ Anti-Nicotinic

Use: Causes Ganglionic Blockade Effects

AEs:

CIs:

Notes:

Question 4

Neuromuscular Blocker

Answer 4

AKA: Nn Selective Nicotinic Antagonists/ Anti-Nicotinic

Use: Muscle paralysis during surgery

AEs:

CIs:

Notes:

Question 5

Muscarinic Antagonists

Answer 5

Use:
Atropine (Bradycardia, AV Block, Anti-ChE toxicity)
Oxybutynin (Overactive Bladder, Enuresis, Neurogenic Bladder)
Ipratropium (COPD, Rhinorrhea)

AEs:
* Dry Mouth (Xerostomia)
* Increased Body Temperature (Decreased sweating,
“atropine fever”)
* Urinary Retention
* Constipation
* Blurred Vision
* Tachycardia

CIs:
Urinary and GI obstruction
Glaucoma

Notes:
* Toxicity: Atropine Intoxication (dry as a bone, hot as
a stone, red as a beet, mad as a hatter, blind as a
bat)
* Tx: Pyridostigmine (Reversible inhibitor of AchE) –>
increase Ach –> stimulation of muscarinic receptors

Question 6

Amphetamine-like Indirect Sympathomimetics

Answer 6

Use:
CNS
Hypotension
Nasal Congestion

AEs:
Cardiovascular: increase BP, increase HR, cardiac arrhythmias
CNS: Paranoia, insomnia, headache, nervousness

Question 7

Endogenous Catecholamines

Answer 7

Use:
Acute Hypotension
Anaphylaxis (epipen, Cardiac Arrest

AEs:
Arrhythmias
Hypertension

Question 8

α Agonists

Answer 8

Use:
Nasal Congestion
Ocular Irritation
Nasal Congestion
Mydriatic Agent
Hypotension

AEs:
Hypertension
Rebound Hyperemia (nasal decongestants only)

Question 9

β Agonists

Answer 9

Use:
Bradycardia
AV Block
Acute HF
Cardiogenic Shock

AEs: Tachycardia/ Arrhythmias

CIs:

Notes:

Question 10

β2 Agonists

Answer 10

Use:
Asthma
COPD

AEs:
Tremors (stimulation on 2R on SKM)
Tachyarrhythmias/Arrhythmias (Cardiac Stimulation, not 100% selective for B2)

Question 11

α Antagonists

Answer 11

Use:
Pheochromocytoma (tumor of chromaffin cells that secrete EPI/NE)

AEs:
Orthostatic Hypotension
Reflex tachycardia

Question 12

α2 Agonists

Answer 12

Use:
HTN
HTN in pregnancy

AEs:
Sedation
Dry Mouth

Question 13

B Antagonists

Answer 13

Use: Cardiovascular Disease

AEs:
Cardiac (Bradycardia, AV block)
Bronchoconstriction