Cholinergic Agonists and Antagonists Flashcards
1
Q
What are the subtypes of ACh receptors?
Where are they located?
A
M1: nerves; IP3, DAG cascade
M2: heart, nerves, smooth m; inhibition of cAMP production, activates K channels
M3: glands, smooth m, endothelium; IP3, DAG cascade
M4: CNS; inhibition of cAMP production
M5: CNS; IP3, DAG cascade
Nm: skeletal m, neuromuscular junction; Na, K depolarizing channel
Nn: postganglionic cell body, dendrites, CNS; Na, K depolarizing ion channel
