Cholinergic Agonists

Question 0

Pilocarpine

Answer 0

direct cholin agonist
CNS pen, increases sweat?
Tx of glaucoma

Question 1

Muscarine

Answer 1

Direct cholinergic agonist

Question 2

cevimeline is selective for which receptor

Answer 2

selective for M3

Question 3

Which drug is resistant to AChE?

Answer 3

Bathanachol:
most GI/Bladder effect
Tx of GI motility problems

Question 4

METHaCholine

Answer 4

could dx asthma

direct musc agonist

Question 5

what are the CIs for direct muscorinic agonists?

Answer 5

Asthma/COPD
Peptic ulcer
Bowel obstruction

Question 6

tx toxicity of direct musc agonists

Answer 6

atropine

albuterol

Question 7

Varenicline

Answer 7

direct nicotinic rec agonist

helps iwth nicotine WD

Question 8

How to tx nicotine toxicity

Answer 8

Atropine
Anticonvulsants (why?)
Assist respiratory

Question 9

Carbachol and Ach are what type of drugs

Answer 9

Direct muscorinic AND nicotinic rec agonist

ACh - short half life

Question 10

Neostigmine

Answer 10

Indirect cholin agonist/ AChE inhibitor (no breakdown of ACh)
poor oral; carbamate
increase bladder motility
reverses NM block after surgery
tx of MYASTHENIA GRAVIS

Question 11

Which drug tx’s Myasthenia Gravis?

Answer 11

Neostigmine

indirect cholin agonist: AChE inhibitor

Question 12

Physostigmine

Answer 12

ENTERS CNS
carbamate
AChE inh
could tx glaucoma

Question 13

Endrophonium

Answer 13

Indirect cholinergic agonist: AChE inh
must inject!
Used to dx Myasthenia Gravis
used to determine if tx dose is right
SHORT acting

Question 14

Organophosphates

Answer 14

indirect cholinergic agonist: AChE inhj
LONG lasting effects
1) give 2-PAM within 2 hrs to prevent AGING
2) Atropine until pupils dilate
3) Diazapam for convulsions
eg DFP< echothiophate, sarin, parathion, malathion