ANS Intro

Question 0

M3

Answer 0

exocrine glands, smooth muscle, endothilium
MOA: PLC -> IP3 and DAG -> Calcium and Protein Kinase (->depol)
MOA same as M1

Question 1

M1 receptor

Answer 1

CNS and SWEAT gland
MOA: increase phophlipase C (PLC) -> produces IP3 and DAG -> increase Ca2+ and activate Protein Kinases (-> depolarizes cell?)

Question 2

M2

Answer 2

heart, smooth m (like M3), presynaptic neurons (decrease NE)
MOA: decrease Adenylyl cyclase -> open K chanels -> HYPERpolarize neuronal cell
Pre-synaptic M2: decrease NE

Question 3

Nicotinic Nn

Answer 3

Post-GANGLIONIC neurons (2nd neuron)

Pre-synaptic terminals

Question 4

Nicotinic Nm

Answer 4

Skeletal Muscle

MOA: bind ACh -> open Na channels -> depolarize cell

Question 5

Alpha 1

Answer 5

smooth m (like (M2-hrt,pre-syn and M3-exocrine, endothilium)
MOA: Gq, increase PLC -> IP2 and DAG -> Ca2+ - > depol cell
(MOA like M1 (sweat) and M3)

Question 6

Alpha 2

Answer 6

pre-synaptic terminals (like M2), platelets, lipocytes, smooth m (like Alpha1, M3 and M2)
MOA like M2: Gi, decrease Adenylyl Cyclase -> open K channels -> HYPERpol
Pre-syn Alpha 2: decrease NE (like M2)

Question 7

Beta 1

Answer 7

heart (like M2), pre-synaptic (like M2) and post-syn
MOA: Gs, increase Adenylyl Cyclase
Pre-syn B: increase NE

Question 8

Beta 2

Answer 8

heart (like M2), post-syn (like B1), smooth m (like A1, M2, M3), bronchioles

Question 9

Beta 3

Answer 9

lipocytes, lipilysis

MOA: increase Adenyly cyclase

Question 10

D1 and D5

Answer 10

Brain, renal vasculature

MOA: increase Adenylyl (Or Adenylate) cyclase

Question 11

D2, D3, D4

Answer 11

Brain (like D1 and D5), various tissues

MOA: decrease Adenylate Cyclase (opposite MOA of D1 and D5)

Question 12

pre-syn M2 and A2

Answer 12

decrease NE

Question 13

Pre-syn Beta

Answer 13

increase NE as opposed to pre-syn M2 and A2