Cholinergic Agonist & antagonist

Question 1

Name the 4 cholinergic Neurons

Answer 1

1. Adrenal medulla (pre-gg)
2. autonomic gg (EN & NE)
3. Post-gg (PS)
4. NMJ

Question 2

Synthesis of Ach made by ____ enzyme

Answer 2

Acetyltransferase (CAT)

AcCoA + Choline = AcH

Question 3

Where is Ach stored ?

Answer 3

vesicles

Question 4

Degradation of Ach done by ____ enzyme

Answer 4

Ach Esterase

Question 5

Which two paths have adrenergic receptors

Answer 5

Adrenal medulla & SP

Question 6

Location of M1 (excitatory) muscarinic receptors

Answer 6

heart, SM, brain, exoxrine

Question 7

Location of M2 (inhibitory) muscarinic receptors

Answer 7

cardiac cells and SM

Question 8

action of pririnzepine

Answer 8

blocks M1 secretion and stomach

* muscarinic antagonist

Question 9

action of betanechol?

Answer 9

stim atonic bladder

Question 10

action of carbachol

Answer 10

mitotic agent of the pupil

Question 11

action of pilocarpine

Answer 11

gdecrease intra-ocular pressure in glaucoma

Question 12

name the 1 muscarinc antagonist

name the 2 nicotinic antagonist

Answer 12

muscarinc: pririnzepine
(blocks excitatory M1)

nicotinic: tubocuarine or succinylchole

Question 13

name 2 anticholinesterase drugs

inhibits Ach esterase

Answer 13

physostigmine

neostigmine

Question 14

drug used for atropine overdose

Answer 14

physostigmine

Question 15

drug used for Myasthenia gravis

Answer 15

neostigmine

Question 16

anticholinesterase drugs can be reactivated by ___

Answer 16

pralidoxime (PAM)

Question 17

drug that is a gg blocker

Answer 17

Nicotine