Cholinergic Flashcards
Acetylcholine
Direct-acting cholinomimetic
Most rapid
Bethanechol
Direct-acting cholinomimetic
Least rapid
Cevimeline
Direct-acting cholinomimetic
Targets M3 receptors and is used for Sjogren’s syndrome (dry eyes + mouth)
Pilocarpine
Direct-acting cholinomimetic
Uncharged
Varenicline (Chantix)
Direct-acting cholinomimetic
Targets nicotinic receptors and is approved for smoking cessation.
Donepezil
Cholinesterase inhibitor
Uncharged - will go to CNS
Edrophonium
Cholinesterase inhibitor
Positively charged and reversible
Neostigmine
Cholinesterase inhibitor
Positively charged and reversible
Physostigmine
Cholinesterase inhibitor
Uncharged - will go to CNS
Pralidoxime
Cholinesterase regenerator
Used in addition to atropine to combat cholinergic poisoning
Scopolamine
Antimuscarinic drug
Used for motion sickness and in ophthalmology
Can cause drowsiness and amnesia
Atropine
Antimuscarinic drug
Used for GI disorders and in ophthalmology
Non-selective muscarinic antagonist
Glycopyrrolate
Antimuscarinic drug
Used for GI disorders
Charged
Tropicamide
Antimuscarinic drug
Used in ophthalmology
Uncharged - can enter CNS
Ipratropium
Antimuscarinic drug
Used for respiratory disorders
Charged