Adrenergic Flashcards
Epinephrine
Direct acting agonist
Beta 2 activation with Epi is»_space; NE
Not orally effective
Used for asthma, anaphylactic shock, glaucoma, local anesthetics, cardiac resuscitation
Norepinephrine (Levophed)
Direct acting agonist A1, A2, B1
Vasoconstriction
Dopamine
Direct acting agonist
D1>a,b
Increases blood flow to kidneys
Phenylephrine
Alpha 1 agonist
Used for nasal decongestants, pressor, inducing bradycardia, glaucoma
Isoproterenol
Beta agonist
Dobutamine
Beta 1 agonist
Albuterol
Beta 2 agonist
Salmeterol
Beta 2 agonist
Long lasting - used at night
Formoterol
Beta 2 agonist
Long lasting - used at night
Midodrine
Alpha 1 agonist
Taken orally to stop orthostatic hypotension
Terbutaline
Beta 2 agonist
Can be taken orally
Amphetamines
Release NE from nerve endings and block its re-uptake
Clonidine
Alpha 2 agonist
Sudden withdrawal causes hypertensive crisis
Phentolamine
Alpha blocker
Prazosin
Alpha 1 blocker
Propranolol
Beta blocker
~25% bioavailability - titrate up for the patient as everyone is different
Sudden withdraw syndrome
Atenolol
Beta 1 blocker
Metoprolol
Beta 1 blocker
Esmolol
Beta 1 blocker
Very short acting
Labetalol
Alpha and beta blocker
Carvedilol
Alpha and beta blocker
Used in CHF cases
Phenoxybenzamine
Alpha blocker
Non-competitive irreversible
Used for Pheochromocytomas, peripheral vascular disease, raynaud’s syndrome, acrocyanosis
Terazosin
Alpha 1 blocker
Used in the treatment of BPH
Doxazosin
Alpha 1 blocker
