Cholesterol-lowering Medication

Question 1

Common prescribed conditions

Answer 1

hyperlipidemia; CVD risk patients; diagnosed CVD patients (e.g. stroke or MI)

Question 2

Reasons for prescribed medications

Answer 2

treats abnormal/high levels of types of fats; reduces risk of atherosclerosis in people w/ risk or w/ disease

Question 3

Classes of lipid lowering meds

Answer 3

1. Statins
2. Cholesterol binding resins
3. Niacin
4. Fibric acid derivatives
5. Cholesterol absorption inhibitors

Question 4

List five HMG-CoA Reductase Inhibitors

Answer 4

1. Atorvastatin
2. Lovastatin
3. Pravastatin
4. Simvastatin

Question 5

Mechanism of HMG-CoA Reductase Inhibitors

Answer 5

inhibits production of cholesterol in liver by blocking enzyme HMG-CoA reductase; increases LDL receptor turnover rate; lowers LDL; modest affect on increasing HDL

Question 6

Mechanism of Fibric Acid Derivatives

Answer 6

lowers TRG; raises HDL levels; most common in some diabetic patients

Question 7

Mechanism of Resins

Answer 7

inhibits liver secreting bile acid; decreases cholesterol break down; interefers with cholesterol reabsorption; lowers LDL

Question 8

Mechanism of Cholesterol Absorption Inhibitors

Answer 8

blocks cholesterol absorption