Cholesterol drugs

Question 1

rate-limiting step in the synthesis of cholesterol

Answer 1

HMG-CoA reductase

Question 2

drugs lower cholesterol by 2 methods:

Answer 2

– decreases synthesis of cholesterol in liver
(so don’t make new cholesterol)

– increases LDL breakdown (decreases
existing bad cholesterol)

Question 3

HMG CoA Reductase Inhibitors side effects:

Answer 3

myalgias***
– statins are associated with causing rhabdomyolysis = a disease characterized by the disintegration of the muscle tissue

Question 4

Important dental drug interaction = red flag drugs:

Avoid use of _____________
and ________________medications in statin users: promotes rhabdomyolysis

Answer 4

macrolide antibiotics (erythromycin)

systemic (azole) antifungal

Question 5

_______is the only drug
in its class:

– decreases intestinal
cholesterol absorption

Answer 5

ezetimibe (Zetia)

Question 6

statin drug (simvastatin) with ezetimibe (Zetia) =

Answer 6

Vytorin

Question 7

statin drug (atorvastatin) with
ezetimibe (Zetia) =

Answer 7

Liptruzet