Cholesterol Flashcards
1
Q
LDL
A
- Delivers cholesterol to various organs
- High Cholesterol/ Triacylglyceride Ratio
- Major Apoliprotein : Apro B-100
- Cause plaques in blood vessels
2
Q
Cholesterol
A
Lipid
Isoprenoid
steroid
3 six carbon ring + 1 five carbon ring
synthesized from acetyl coA
3
Q
Statins
A
inhibit HMG-CoA reductase
reduce cholesterol levels
4
Q
Inhibitors of HMG-CoA reductase
A
- Cholesterol
- Glucagon
- Bile Acid
- Mevalonate
5
Q
What is the activated carrier needed for cholesterol synthesis
A
CoA
6
Q
Functions of Lipoproteins
A
transport lipids in blood
7
Q
four main classes of lipoproteins
A
Chylomicrons
VLDL
LDL
HDL
8
Q
Lipases
A
hydrolyze the triacylglyceride being delivered into fatty acids and glycerol
9
Q
Bile Acid
A
- Cholesterol Excreition
- Emulsification of lipids in the intestine
- increase lipase activity in the intestine
- Produced in the liver -> gallbladder(stored)
10
Q
Lipoproteins has higher cholesterol content relative to triacylglycerol content:
A
HDL
LDL
11
Q
Lipoproteins deliver lipids to the liver
A
Chylomicron
HDL
LDL
12
Q
Lipoproteins delivers lipids to peripheral (non-liver) cells
A
Chylomicron
VLDL
LDL
13
Q
Clofibrate
A
- lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood.
- It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and reduce the level of VLDL.
- It can increase the level of HDL as well
14
Q
Ezetimibe
A
- reduces blood cholesterol levels by inhibiting the absorption of cholesterol by the intestine by blocking uptake
15
Q
CETP (cholesterol ester transfer protein )
A
- exchanges the cholesterol esters in the HDL for triglycerides from LDL
- HDL3 becomes HDL2
