Arachidonic Acid Metabolism

Question 1

Eicosanoids

Answer 1

Derived from arachidonic acid and EPA

Lipid signaling molecules that activate GPCR

Question 2

4 main types of Eicosanoids

Answer 2

• Prostaglandins
• Prostacyclins
• Thromboxanes
• Leukotrienes

Question 3

Prostanoids

Answer 3

prostaglandins, prostacylins, and thromboxanes

Question 4

Arachidonic Acid

Answer 4

Omega 6 fatty acid

Derived from linoleic

Question 5

EPA

Answer 5

Omega 3

derived from Linolenic acid

Question 6

Cox 1 & 2 pathway of Arachidonic Acid

Answer 6

Group 2 Prostanoids (TXA2, PGE2, PGI 2 )

Pro-inflammatory

Question 7

LOX pathway of Arachidnic Acid

Answer 7

Group 4 Leukotrienes or Lipoxins

Pro inflammatory

Question 8

COX 1 & 2 pathway of EPA

Answer 8

Group 3 Prostanoids

not pro inflammatory

Question 9

Lox pathway of EPA

Answer 9

group 5 Leukotrienes or lipoxins

not pro-inflammatory

Question 10

Thromboxanes

Answer 10

• Highly active metabolites of prostaglandins
• Group 2 Thromboxanes have thrombus-forming potential (TXA2 - produced by activated platelets and promotes platelet aggregation)

Question 11

Cyclooxenenase (PGS)

Answer 11

• catalyzes the conversion of arachidonic acid to PGG2 xia oxidation
• blocked by NSAIDS

Question 12

COX-2 inducers

Answer 12

Cytokines, Growth Factors ,TNF-a

Results in inflammatory Prostaglandins

Stimulate hypothalamic fever response

Sensitize skin pain

Question 13

COX pathway for EPA

Answer 13

Group 3 prostanoids

not imflammatory