Choking, Anaphylaxis, and Paracetamol overdose Flashcards

1
Q

What are the features of a partial airway obstruction?

A
  • will only block part of the airway
  • productive cough will be evident
  • noisy airway due to blockage
  • needs encouragement to cough
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the features of a complete airway obstruction?

A
  • fully closes off the airway
  • unproductive cough evident
  • no noise coming from airway due to complete blockage
  • needs fast intervention from rescuer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When a patient has an airway blockage what should you do?

A

encourage the pt to cough, if effective cough is present, encourage pt to cough more and gently pat back to help

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If you encourage a patient to cough and an ineffective cough is present, what should you do?

A

advise patient to stand and lean them forward, support them across their shoulder at the from with one arm and position yourself to the side of the patient and give 5 hard back blows

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do you give back blows?

A

between the shoulder bladed at the back with the flat of tour hand, checking between each blow for signs of change

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

If you complete 5 back blows and they are unsuccessful, what should you do?

A

perform 5 abdominal thrust by making a fist under the point of the patient’s ribcage at the diaphragm muscle, grab first with other hand and pull inwards and upwards in a short sharp motion (J shape), check between each thrust for signs of change

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

If you complete 5 abdominal thrust and there is stil no sign of recovery from the patient what should you do?

A

phone ambulance early if no sign of recovery from patient, repeat the process until one of 2 things happens; the item dislodges or the patient collapses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

If a choking patient collapses what should you do?

A

ensure the ambulance is updated and begin CPR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the 2 caveats when managing a choking patient?

A
  • pregnant women only get back blows due to the risk to the babies life during abdominal thrust manoeuvre
  • bariatric patients will only get back blows it you cannot physically get your arms around to perform abdominal thrusts

RCUK advises attempting to place hands higher up the sternum is possible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does ABCDE stand for?

A

Airway
Breathing
Circulation
Disability
Exposure/everything else

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What happens to the body during anaphylaxis?

A
  • the body repsonds to the trigger which causes the immune system to release a flood or chemicals which can cause the patient to go into shock
  • it does this in response to this potential threat enter the body further
  • spotting the signs and symptoms early is critical to the outcome of the patient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the ABCDE signs and symptoms fo anaphylaxis?

A

A - stridor, wheezing
B - increased RR (as high as 30), decreased Sp02, rapid shallow breaths
C - drastically decreased BP due to vasodilation, increased CRT, tachycardia, bounding pulse
D - ACVPU: A but with sense of impending doom, glucose NA
E - flushing, urticarial rash, angioedema of lips, nose, tongue. Stomach cramps, urinary incontinence, bowel incontinence, vomiting, nausea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is anaphylaxis managed?

A
  • phone 999 and state anaphylaxis
  • remove the source (if known)
  • try to lay patient in supine position to restore BP
  • administer 1:1000 adrenaline IM 0.5mg (1mg/1ml) recommended in the anterolateral thigh
  • 02 - 15L/min via non re-breather mask
  • if patient has autoinjector then use this first before using adrenaline on emergency kit
  • repeat after 5 mins if required
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the dosage of adrenaline to be given to a 9 month-5 year old to treat anaphylaxis?

A

0.15mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the dosage of adrenaline to be given to a 6-11 year old to treat anaphylaxis?

A

0.3mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the dosage of adrenaline to be given to a 12-17 year old to treat anaphylaxis?

A

0.5mg

17
Q

Why is adrenaline given to treat anaphylaxis?

A

main benefit = vaso-constrictor, squeezes the peripheral vessels to ensure that blood and fluid is forced back towards the heart. By going this, blood pressure should increase and angioedema should reduce significantly

18
Q

What are the steps in the paracetamol OD algorithm?

A
  1. identify all paracetamol containing medications
  2. calculate total dose in last 24 hours
    IF MORE THAN 4g IN 24 HOURS:
  3. weigh the patient, if weight >110kg use 110kg in calculation to avoid underestimating dose
  4. calculate dose in mg/kg in 24 hours
  5. take careful note of certain conditions in patient’s medical history
    IF MORE THAN 75mg/kg (or any doubt etc):
    - consult TOXBASE, phone NPIS, if neither available then A&E
19
Q

What dosage of paracetamol in mg/kg is of concern?

A

> 75mg/kg

20
Q

If you suspect they may have overdosed on paracetamol, what conditions should be taken careful note of in the patient’s medical history?

A
  1. alcoholic liver disease
  2. cystic fibrosis
  3. chronic liver disease
  4. an eating disorder/fasting
  5. regular intake of enzyme inducing drugs
  6. significant alcohol intake
  7. HIV
21
Q

What are some examples of enzyme-inducing drugs?

A
  • rifampicin
  • phenytoin
  • carbamazepine
  • phenobarbitone
  • primodone
22
Q

How do you find the landmark where you should perform abdominal thrusts?

A

finding the bellybutton with thumb at one hand and creating a fist, then roll up into position (between umbilicus and xiphisternum)

23
Q

What is the common name for paracetamol in other countries?

A

acetaminophen

24
Q

What is the maximum therapeutic paracetamol dose for adults?

A

4g in 24 hours

25
Q

What is a an acute overdose?

A

excessive ingestion over a period of <1 hour in the context of self harm

26
Q

What is a staggered overdose?

A
  • excessive ingestion over >1 hour in the context of treating pain (therapeutic overdose)
  • can also occur with intent of self harm (non-therapeutic overdose
27
Q

In what period of time does therapeutic paracetamol excess occur?

A

usually over more than 24 hours, but can be over less than 24 hours

28
Q

What are the 3 categories of toxicity?

A
  • serious toxicity
  • likely toxicity
  • unlikely toxicity
29
Q

What does the body become deficient in when it has overdosed on paracetamol?

A

glutathione

30
Q

What categories of patients are at a higher risk of liver injury secondary to paracetamol excess due to depleted glutathione?

A
  • malnourishment (fasting for more than a day)
    • eating disorders (e.g. anorexia, bulimia)
    • cachexia
  • psychiatric disorders
  • chronic disease (HIV, cystic fibrosis, liver disease)
  • alcohol-use disorder
31
Q

What kind of long term medications can increase a patient’s risk of liver injury secondary to paracetamol excess?

A

Cytochrome P450 inducers

32
Q

What are some common cytochrome P450 inducers?

A
  • anti epileptics
  • barbiturates
  • antibiotics
  • anti-retrovirals
  • st. john’s wort
33
Q

What are common signs of paracetamol excess within the first 24 hours?

A
  • nausea and vomiting
  • general abdominal pain
34
Q

What are signs of acute liver injury 2-3 days after paracetamol excess?

A
  • RUQ abdominal pain
  • jaundice - sign of acute liver injury
  • hepatomegaly
  • reduced GCS
  • loin pain/AKI
  • abnormal LFTS/metabolic acidosis
35
Q

In terms of paracetamol excess, what patients should be discussed/referred to hospital for medical assessment?

A
  1. symptomatic patients
  2. patients who have taken more than a licensed daily dose AND more than or equal to 75
  3. patients who have ingested more than the licensed daily dose but less than 75mg/kg/24 hours on each of the preceding 2 or more days
36
Q

What is used to treat paracetamol overdose?

A

acetylcysteine IV (NAC, Parvolex)

37
Q

What does acetylcysteine IV (NAC, parvolex) do?

A

increases hepatic glutathione
- near 100% efficacy in preventing paracetamol-induced hepatotoxicity if given within first 8 hours from ingestion
- may still be effective >24 hours

38
Q

How is acetylcysteine IV (NAC, parvolex) given?

A

NAC given in 2 IV infusion
- biochemistry, coag screen, blood gases monitored during infusion