Chlamydia Flashcards

1
Q

Describe Chlamydia

A
Obligate Intracellular
Gram Neg/Variable
STain purple wiht Giemsa
Does not produce it's own ATP
NO PEPTIDOGLYCAN -> has PBP though
Penicillin not effective
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2
Q

Describe the life cycle of Chlamydia Thrachomatis

A

Infect cell -> form Reticulate Bodies -> Multip/ly ->Reorganize to Elementary Body -> Mature Inclusions -> Release of infectious Elementary Bodies-> repeat

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3
Q

What kind of response causes the disease?

A

It is not a necrotic type of infection

Inflmmatory response causes disease and spread

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4
Q

Which form of Chlamydia Trachomatis is infectious?

A

Elementary Body

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5
Q

What are the species of Chlamydiaceae?

A

Chlamydia trachomatis

Chlamydophila: C.Psittaci, C.Pneumoniae

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6
Q

Describe the pathogenesis of Chlamydia infection?

A

Access via minor abrasions-> cell damage-> induce severe inflammatory response

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7
Q

What diseases can C.Trachomatis cause?

A

Chronic follicular Conjunctivitis: Serotypes A-C
Genital Tract Infection: Serotype D-K (STD form)
Inclusion Conjunctivitis: Serotypes D-K (STD form)
Neonatal Peumonia
Lymphogranuloma Venereum: Serotype L1-L3

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8
Q

Which serotypes cause chronic folicular conjunctivitis? How is this disease treated?

A

A-C

Tx: Surgery and Tetracycline topical ointment, Azithromycin (macrolide)

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9
Q

What is the clinical presentation of the STD form of C.Trachomatis?

A

Genital Tract infection
Men have more sx than women -> asymptomatic carriers in women common
Urethritis, epidymitis, prostatitis
Cervicitis, potential PID leading to infertility

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10
Q

Why must pregnant women be screened for C.Trachomatis?

A

Can cause infant pneumonia and conjunctivitis

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11
Q

Which serotypes cause genital tract infections?

A

Serotypes D-K

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12
Q

What is inclusion conunctivitis and how is it treated?

A

Most common cuase of neonatal conjunctivitis due to contact with vaginal secretions of infected woman
Serotype D-K
Tx: Tetracycline

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13
Q

Which serotypes cause lympgranuloma venereum?

A

L1-L3

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14
Q

What is the presentation of lymphgranuloma venereum

A

Suppurative Multilocula Inguinal Lymph Nodes (bubos)
Perirectal aabscesses
Fistula drainage

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15
Q

How is C.Trachomatis Diagnosed?

A

Epithelial Scrapings -> culture
DFA: direct fluorescent antibody (high sensitivity, high specificity)
DNA probe
Serology

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16
Q

What are the treatment options for C.Trachomatis?

A

Tetracycline
Quinolones
Azithromycin
Erythromycin

Remember, these are penicillin INSENSITIVE

17
Q

What are the 2 different forms of clinical presentations of C.Pneumonia infection?

A

Pharyngitis and Laryngitis w.out pneumonia
Or
Pneumonia only

18
Q

How is C.Pneumonia diagnosed?

A

Serology, but rarely

19
Q

What are teh protocols for CA-Pneumonia?

A

Strep Pneumo
Mycoplasma
C.Pneumonia (atypical)

Tx with broad based therapy -> Fluoroquinolones

20
Q

What are the treatment options for C.Pneumoniae?

A

Moxifloxacin (fluoroquinolone)
Erythromycine
Tetracycline

21
Q

What is Chlamydophila Psittaci?

A

Zoonosis infection acquired from birds via inhalation

Affects lower respiratory tract

22
Q

How is C.Psittaci diagnosed and treated?

A

Complement fixation
Epidemiology

Tx: Tetracycline, Erythromycine