Chlamydia Flashcards
Describe Chlamydia
Obligate Intracellular Gram Neg/Variable STain purple wiht Giemsa Does not produce it's own ATP NO PEPTIDOGLYCAN -> has PBP though Penicillin not effective
Describe the life cycle of Chlamydia Thrachomatis
Infect cell -> form Reticulate Bodies -> Multip/ly ->Reorganize to Elementary Body -> Mature Inclusions -> Release of infectious Elementary Bodies-> repeat
What kind of response causes the disease?
It is not a necrotic type of infection
Inflmmatory response causes disease and spread
Which form of Chlamydia Trachomatis is infectious?
Elementary Body
What are the species of Chlamydiaceae?
Chlamydia trachomatis
Chlamydophila: C.Psittaci, C.Pneumoniae
Describe the pathogenesis of Chlamydia infection?
Access via minor abrasions-> cell damage-> induce severe inflammatory response
What diseases can C.Trachomatis cause?
Chronic follicular Conjunctivitis: Serotypes A-C
Genital Tract Infection: Serotype D-K (STD form)
Inclusion Conjunctivitis: Serotypes D-K (STD form)
Neonatal Peumonia
Lymphogranuloma Venereum: Serotype L1-L3
Which serotypes cause chronic folicular conjunctivitis? How is this disease treated?
A-C
Tx: Surgery and Tetracycline topical ointment, Azithromycin (macrolide)
What is the clinical presentation of the STD form of C.Trachomatis?
Genital Tract infection
Men have more sx than women -> asymptomatic carriers in women common
Urethritis, epidymitis, prostatitis
Cervicitis, potential PID leading to infertility
Why must pregnant women be screened for C.Trachomatis?
Can cause infant pneumonia and conjunctivitis
Which serotypes cause genital tract infections?
Serotypes D-K
What is inclusion conunctivitis and how is it treated?
Most common cuase of neonatal conjunctivitis due to contact with vaginal secretions of infected woman
Serotype D-K
Tx: Tetracycline
Which serotypes cause lympgranuloma venereum?
L1-L3
What is the presentation of lymphgranuloma venereum
Suppurative Multilocula Inguinal Lymph Nodes (bubos)
Perirectal aabscesses
Fistula drainage
How is C.Trachomatis Diagnosed?
Epithelial Scrapings -> culture
DFA: direct fluorescent antibody (high sensitivity, high specificity)
DNA probe
Serology