Childhood Diseases Flashcards
1
Q
RSV pathogenesis: (MOI: in body and specific cells)
how does it spread w/in body
A
- infection in lower/upper respiratory tract
- infects ciliated mucosal cells of nose, eyes, and mouth
- spreads extracellularly & via fusion of cells (syncytia)
2
Q
Diseases it can cause
A
resp. syndromes
ear infect. in children
3
Q
RSV family
A
Paramyxoviridae
4
Q
RSV genera
A
Pneumovirus
5
Q
RSV Epid.
MOT
TXT
A
- distributed worldwide
- source = human respiratory tract
- MOT:direct person to person contact
- TXT: no vaccine, Palivizumab
6
Q
+ FDA approved treatment for RSV
A
palivizumab - humanized monoclonal antibody (passive immunity) to block membrane fusion protein
- not effective for txt.
7
Q
Poliovirus genera
A
enterovirus
8
Q
Poliovirus family
A
Picornaviridae
9
Q
Polio host
A
only humans
10
Q
Polio MOI
A
invade epithelial cells lining digestive tract and CNS
11
Q
Polio MOT
A
fecal-oral, salivary/respiratory droplets
12
Q
Polio Paralytic Disease
outcome:
A
muscle inv. peaks few days after paralytic phase begins
outcome: paralysis usually irreversible; resin. paralysis in life
13
Q
types of polio
A
spinal and bulbar
