Childhood Disease III Flashcards
fibrous tumors are most often what
benign
what is the only malignant fibrous tumor we talked about
congenital infantile fibrosarcoma
what does infantile myofibromatosis look like
nodules on infant
what is the most common fibrous tumor in infants
infantile myofibromatosis
aggressive infantile fibromatosis
still benign but can grow large and infiltrate
myofibroblast cells infiltrate skeletal muscle
what is the most common solid tumor in the newborn
sacroccygeal teratoma
what is the most common solid congenital malignancy
congenital neuroblastoma
most of the sacrococcygeal tertomas detected before 4 months of age are _______
benign
what is the second leading cause of death from disease in age 5-14
malignancy
what are teh 3 major sources of childhood malignancy
hematopoiectic
nervous
renale
why does childhood malignancy have a favorable prognosis
tendency of spontaneous regression
neuroblastoma
malignant tumor of primaritvie sympathetic cells
affects adrenal medulla, sympathetic ganglia
what is the cause of 10% of all childhood cancers
neuroblastoma
what are some symptoms of neuroblastoma
abdominal mass
weight loss
ascities
how does neuroblastoma affect blood
increased catecholamines
how does neuroblastoma affect urine
increased VMA and HVA
buzzword for neuroblastoma
blueberry muffin baby
what does neuroblastoma look like histologically
small blue round cells
dense core neurosecretory granules
what is the most common primary malignant tumor of kidney in children
wilms tumor
what is wilms tumor associated with
mutations and congenital malformations
symptoms of wilms tumor
abdominal mass
hematuria
fever
hypertension
WAGR syndrome
33% risk to have WT
retardations
genital anomalities
no iris
denys-drash syndrome
90% risk to have WT
nephropathy
gonadal dysgenesis
gonadoblastoma
what is the most common sarcoma of childhood
rhabdomyosarcoma
where is rhabdomyosarcoma most often located on the body
head and neck, specifically around the eyes
what are the 3 subtypes of rhabdomyosarcoma
embryonal
alveolar
pleomorphic
what subtype of rhabdomyosarcoma has the worst prognosis
pleomorphic
where does embryonoal rhabdomyosarcoma often develop
walls of hollow, mucosal-lined structures
some things taht retal alcohol can cause
growth retardnation microcephaly short palpebral fissures maxillary hypoplasia atrial septal defect
neural tube defects
an opening in spinal cord or brain that occurs very early in human development
what can reduce the incidence of neural tube defects
folic acid supplements
what is the indicator of fetal lung maturity
surfactant
what is surfactant
mixture of lipids, proteins, glycoproteins - lecithin and spingomylin
neuroblastoma
malignant tumor of primative sympathetic cells
affects adrenal medulla, sympathetic ganglia
some things that fetal alcohol can cause
growth retardation microcephaly short palpebral fissures maxillary hypoplasia atrial septal defect
