CHF (EXAM 4) Flashcards

1
Q

CHF is the most common __________ diagnosis in the U.S. in those > 65

A
  • inpatient
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the important epidemiology factors for CHF?

A
  • very common!
  • incidence increases with age (75% of cases are in those > 65)
  • M > F
  • 25% higher incidence in African American patients
  • some forms of cardiomyopathy are genetic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Who is the most at risk for developing CHF?

A

Those with:

  • Coronary heart disease
  • Smokers
  • HTN
  • Obesity (huge risk factor!)
  • Diabetes
  • Valvular heart disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Heart function and cardiac output depend on these 4 thing:

A
  • contractility of myocardium
  • preload of the ventricle
  • afterload applied to ventricles
  • heart rate

(issues with any of these 4 factors can result in CHF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is this the definition of?

  • the pressure in the ventricle at the end of diastole
A

PRELOAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

AFTERLOAD: They systemic ________ ________ (pressure) that the heart works ______ to pump blood (pressure in the ventricle wall during ejection)

A
  • vascular resistance

- against

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe the Frank-Starling Law

A
  • Stroke Volume (SV) of the heart increases in response to increase in the volume of blood filling the heart (end diastolic volume)

aka - increase in the volume of blood going into the ventricle during diastole = more stretch of ventricle = increased force of contraction and quantity of blood pumped during systole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the #1 and #2 most common causes of CHF in the U.S?

A

1 –> MI

#2 --> Untreated/inadequately treated HTN
       - remember: HTN increases the LV afterload --> 
         longterm this can result in LV hypertrophy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of dysfunction is this describing?

  • ventricular filling is abnormal
  • mycocardial relaxation is impaired or chamber is noncompliant (stiff)
A

DIASTOLIC DYSFUNCTION

  • Slowed, delayed, and incomplete myocardial relaxation
  • Increased dependence on LV filling from atrial contraction
  • Increased passive stiffness and decreased distensibility of the LV
  • Shift of filling from early to late diastole
  • stiffness comes from excess hypertrophy/compositional changes of myocardium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

_________ dysfunction - is an abnormality of diastolic relaxation, filling, or distensibility of the LV, regardless of symptoms of EF

A

Diastolic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

HFpEF is? Describe it

A

Heart Failure Preserved Ejection Fraction

  • clinical signs and symptoms of heart failure, LV diastolic dysfunction, and a normal LVEF
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is generally considered a normal EF%?

A

> 50% (varies slightly by clinic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

_________ is the most common mechanism of SYSTOLIC DYSFUNCTION

A

Ischemia

Another important mechanism:
- decreased LV ejection fraction (EF) < 40-50%

Other causes:

  • idiopathic dilated cardiomyopathy
  • inflammation (ex: myocarditis)
  • infiltration (ex: amyloidosis)
  • toxin-induced cardiomyopathies (ex: cocaine, ethanol)
  • valvular heart disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Adaptations to heart failure Part I:

  • if SV is ________ by high afterload or ________ contractility, pressure and EDV ________.
A
  • if SV is DECREASED by high afterload or DECREASED contractility, pressure and EDV INCREASE.
    - leads to dilated ventricles if chronic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Adaptations to heart failure Part II:

Reduced CO causes:
- ________ sympathetic activity leads to: ________ myocardial contractility, ________ HR, and __________ venous tone.

  • _________ of renal blood flow and GFR.
A
  • INCREASED sympathetic activity leads to: INCREASED myocardial contractility, INCREASED HR, and INCREASED venous tone.
    - leads to ventricular modeling and progressive
    ventricular dysfunction
  • REDUCTION of renal blood flow and GFR.
    - leads to RAAS system activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which side of heart failure is this?

  • Impairment in adequate circulation of blood into systemic circulation –> blood backs-up into the pulmonary vasculature causing pulmonary edema and dyspnea
A

LEFT

(Left sided = think Lungs!)

  • may hear crackles
  • can be systolic or diastolic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

And what about this side for heart failure?

  • Unable to adequately pump venous blood into the pulmonary circulation –> fluid backs up into the body leading to peripheral edema, increased JVP, and ascites
A

RIGHT

**often caused by left heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What body system is very connected to the heart other than pulmonary?

A

RENAL!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Cardio______ Syndrome

A
  • CardioRENAL Syndrome
  • acute or chronic dysfunction of the heart or kidneys can induce acute or chronic dysfunction in the other organ system

**Remember - heart, lungs, and kidneys are all very connected!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What can trigger decompensated HF?

Hint: think about blood volume, issues with rhythm, blood flow, etc

A
  • uncontrolled HTN
  • Increased salt & water intake (or noncompliance with
    diuretics)
  • tachyarrhythmias (esp. new onset afib)
  • ischemia
  • worsening renal failure
  • anemia
  • chronic lung disease
  • infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the prominent symptom of LEFT sided heart failure?

Name 3 other symptoms along with the above.

A
  • DYSPNEA
    (Progression: DOE –> orthopnea, PND –> dyspnea at rest)
  • chronic non-productive cough
  • fatigue
  • exercise intolerance
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

________ retention is the prominent symptom of RIGHT sided heart failure.

A
  • FLUID retention
23
Q

How many classes of heart failure does the NYHA classify? Describe them! (I know I am annoyed by this one too!)

*Paulson said to know these well!

A
  • FOUR

I –> No limitation of physical activity. Asymptomatic.

II –> Slight limitation of physical activity. Comfortable at
rest. Ordinary physical activity results in fatigue,
palpitation, dyspnea, or angina.

III –> Marked limitation of physical activity. Comfortable
at rest. Less than ordinary activity leads to fatigue,
palpitations, dyspnea, or angina.

IV –> Unable to cary out ANY physical activity without
discomfort. Symptoms of heart failure at rest. If any
physical activity is undertaken, discomfort worsens.

24
Q

PE:

What might you see on a patient’s vital signs when they present with CHF?

A
  • Tachycardia
  • Hypotension OR Hypertension
  • Hypoxia
25
PHYSICAL EXAM: What might a respiratory exam show? (4 things)
- dyspnea during activity or conversation - cyanotic - crackles on auscultation (wheeze/ronchi also possible) - dullness to percussion
26
PHYSICAL EXAM: What might the cardiovascular exam show? (7 things)
- parasternal lift - laterally displaced PMI - elevated JVP - peripheral edema (legs, ascites, scrotum, sacral) - pulse alternans (alternating strong & weak pulses) - S3 OR S4 gallop - cool extremities **NOTE OTHER SIGNS: You may also see HSM and hepatojugular reflux.
27
What labs do you want to get on this patient? | 5 potentials
- BNP - CBC - BMP - Troponin (caution here - only order if you suspect CHF caused by ACS; otherwise you may have opened pandora's box) - TSH
28
BNP FACTS: - hormone released from the ________. - plasma concentrations are increased in patients with ___ _________. - Helpful if diagnosis is uncertain: - < 100: high ________ predictive value. - 100-400: not particularly useful. - > 400: most _______ patients w/ heart failure. - has ________ significance - multiple limitations
- hormone released from the HEART. - plasma concentrations are increased in patients with LV DSYFUNCTION. - Helpful if diagnosis is uncertain: - < 100: high NEGATIVE predictive value. - 100-400: not particularly useful. - > 400: most DYSPNEIC patients w/ heart failure. - has PROGNOSTIC significance - multiple limitations
29
What are the limitations of BNP? | 5 of them
- elevated in renal dysfunction and afib - lower in obesity - chronically elevated in some - high levels do not exclude other diseases - normal values increase with age
30
True or false - the below is the comprehensive list of imaging you would want to get on this patient. - EKG - CXR
FALSE! - ECHO - always get the ECHO! - can differentiate b/t HFrEF and HFpEF - EKG - CXR
31
List the lifestyle modifications you would educate this patient on (7 items)
- smoking cessation - restrict/abstain from alcohol - abstain from drug use - restrict sodium intake - may need to fluid restrict (for refractory patients esp. with hyponatremia) - avoid obesity - daily wt monitoring
32
How are we going to treat our patient with HFpEF? | 5 treatments
- control the HTN - diuretics to take off excess volume - manage comorbidities (esp. cardiovascular) - cardiac rehab (only intervention shown to improve QoL/exercise capacity) - Meds: None proven to be effective
33
Furosemide (Lasix) is a _____ diuretic. What does it do, and what do we need to watch out for?
- LOOP diuretic - relieves sign & symptoms of volume overload (edema, dyspnea) - IV more potent than PO - must maintain long-term to prevent recurrence of volume overload - WATCH OUT FOR: hypokalemia, increased BUN/Cr, hypomagnesemia, dizziness, hypotension, hypo OR hypernatremia, ototoxicity
34
What are the other Loop Diuretics?
- Bumetanide (Bumex) - Torsemide (Demedex) - Ethacrynic Acid (Edecrin) *BID works best for Lasix
35
What are the two main Thiazide Diuretics? What do we need to watch-out for with these guys?
- Metolazone (Zaroxolyn) - HCTZ ``` - BE CAREFUL! --> watch for: electrolyte disturbances, massive diuresis (these guys are potent AF) ``` ** can combine with a loop diuretic for refractory edema
36
What about HFrEF; how are we going to treat this? | 6 treatments
- treat contributing factors/assoc. diseases - improve the symptoms (diuretics, ARB, digoxin, and the below) - Meds: Improve morbidity & mortality - Beta-Blockers - ACEI - ARNI - Aldosterone agonists - Hydralazine + nitrate - device therapy (if indicated) - cardiac rehab (class II-III pts) - serial assessment/close follow-up
37
_____ is considered first line and should be given to ALL patients with HFrEF as it improves survival/symptoms, and reduces hospitalizations. ______ is a common patient complaint with these meds.
ACEI; COUGH - ARB is alternative if not tolerated - also watch out for: dizziness, hyperkalemia, angioedema, ARF
38
Name the 3 most common ACEI inhibitors for CHF
- Lisinopril - most commonly used - start with 5mg - Enalapril - Captopril
39
Beta-Blockers ________ the LV size, _______ the EF over time, and ________ the ventricular contraction rate.
- Beta-Blockers REDUCE the LV size, INCREASE the EF over time, and DECREASE the ventricular contraction rate.
40
The 3 most commonly used Beta-Blockers for CHF are?
** the 'lols' - Carvedilol (Coreg) - Metoprolol succinate (Toprol XL) - Bisoprolol (Zebeta) - watch out for: dizziness, edema, hypotension
41
Who is recommended to receive an Aldosterone Receptor Blocker? (3 groups)
- those with NYHA class II AND LVEF ≤ 30% OR - those with NYHA class III-IV AND LVEF ≤ 35% - post-STEMI pts already on ACEI with LVEF ≤ 40% with either symptomatic heart failure OR diabetes
42
What are the two most common Aldosterone Receptor Blockers, and why do we use them in CHF?
- Spironolactone (Aldactone) - Eplerenone (Inspra) - reduces CV death and hospitalization - watch for: hyperkalemia, creatinine
43
Hydralazine + Nitrate (Isosorbide dinitrate) act by: venous & arterial ___________ to _______ cardiac preload and afterload.
- Hydralazine + Nitrate (Isosorbide dinitrite) act by: venous & arterial VASODILATION to DECREASE cardiac preload and afterload.
44
What two groups of patients is Hydralazine + Nitrate (Isosorbide dinitrate) recommended for?
- best mortality benefit seen in black patients when added to optimal therapy - NYHA class III-IV with LVEF < 40% - patients who are unable to tolerate ACEI/ARB - watch for: symptomatic hypotension, HA, dizziness compliance
45
What is an alternative medication class for patients with NYHA Class II-IV with LVEF ≤ 40% given in place of ACEI/ARB?
- ARNI's! - newer drug class, but $$$ - some recommend as initial therapy - lots of good data coming out on these guys
46
What do ARNI's do? Name one example of an ARNI used in CHF.
- reduce CV mortality, all-cause mortality, and hospitalizations - Sacubitril-Valsartan (Entresto)
47
_______ is a positive inotrope that is used to ________ heart contractility.
- DIGOXIN is a positive inotrope that is used to | INCREASE heart contractility.
48
When do we give Digoxin to CHF patients and how do we monitor its levels?
- given for symptom control in patients already on appropriate therapy - levels are monitored by SERUM DIGOXIN CONCENTRATION
49
What do we need to keep in mind when prescribing Digoxin to CHF patients? (4 things)
- Narrow therapeutic window --> 0.7 - 1.2 serum concentration is optimal - Must use RENAL DOSING - Levels can be increased by: Amiodarone, Quinidine, and Verapamil - watch out for: cardiac arrhythmias, visual disturbances, N/V, anorexia **remember you cannot dialyze Digoxin out! Must use Digibind to clear
50
What are the indications for device Therapy in CHF?
- ICD for primary or secondary prevention of sudden cardiac death -vtach/vfib = mcc of sudden cardiac death - cardiac resynchronization therapy (CRT) with biventricular pacing - improves symptoms for patients reduced EF and prolonged QRS
51
What is the initial treatment for someone with Acute Decompensated CHF? (sorry this one is a bit rough)
INITIALLY: - supplemental O2 - assisted ventilation (if needed) - IV loop diuretic - if loop naive: if no response to initial dose, DOUBLE the dose Q2hrs (likely need to increase starting point for renal insufficiency or severe HF) - if chronically take loops: initial IV dose needs to be ≥ their maintenance total daily PO dose MONITOR: - electrolytes and renal function closely
52
What can patients do to prevent CHF? | 6 things
- smoking cessation - avoid excessive alcohol use/cocaine use - regular exercise - low fat diet to prevent CAD - control their HTN - prevent readmission (home wt monitoring, salt restriction, pt diuretic adjustment, case management)
53
What are some things to remember about prognosis with CHF? | 6 items
- hospitalization is a marker for poor prognosis - survival of HF patients worsens with age - better survival for women over men - HFpEF has a better prognosis - 30-50% will be readmitted w/in 3-6 months - main cause of death: sudden or arrhythmic death, progressive pump failure