CHF and valve disease Flashcards
1
Q
Cardiac output
A
- CO= HR X SV
- how much blood is ejected in one min
2
Q
HR
A
- how many times heart beats per min
3
Q
SV
A
- how much blood is ejected with each beat
4
Q
preload
A
- loading condition of heart at end of diastole right before systole
- max diastolic stretch for that contraction
- mainly det by venous return
5
Q
cardiac contractility
A
- ability of heart to contract
6
Q
inotropic influence
A
- increases contractility
7
Q
positive inotropes
A
- digitalis
- sympathetic sitmulation
8
Q
neg inotropes
A
- akinesis secondary to MI
9
Q
LVEF
A
- % of blood leaving heart each time it contracts
- normal= 55-65%
10
Q
frank starling curve
A
- preload on X axis
- SV on Y axis
- further you stretch the heart the more vigorous the contraction
- once heart is stretched too much results in dysfunction
11
Q
what is the more common type of HF
A
- diastolic HF
12
Q
low output HF
A
- pumping or filling ability impaired
- most common type
13
Q
high output HF
A
- excessive need for cardiac output
- much more rare
- Beri-beri
- anemia
- thyrotoxicosis
14
Q
right sided HF
A
- blood backs up into systemic venous system
- legs
- hepatic veins
- GIT
15
Q
causes of right sided HF
A
- left sided HF most common
- severe or chronic pulm disease
- pulmonic valve stenosis
16
Q
left sided HF
A
- blood backs up into lungs -> pulmonary edema
- blood will eventually back up into ride side of heart -> systemic venous sys
- systolic and/or diastolic dysfunction
17
Q
causes of left sided HF
A
- acute MI
- chronic CAD/ multiple MI
- cardiomyopathies
- LVH d/t HTN
18
Q
systolic dysfunction
A
- impaired ejection of blood from heart during systole
- HFrEF
- causes reduced SV
19
Q
causes of systolic dysfunction
A
- ischemic heart disease most common
- idiopathic dilated cardiomyopathy
- HTN
- valve disease- mitral valve regurg
20
Q
diastolic dysfunction
A
- impaired filling of ventricles
- HFpEF
- causes reduced SV
21
Q
causes of diastolic dysfunction
A
- long standing HTN most common
- restrictive cardiomyopathies
- valve disease- mitral valve stenosis
22
Q
what system is used to classify HF
A
- NY heart association functional classifications
23
Q
class I HF
A
- sx only with significant activity
24
Q
class II HF
A
- sx with ordinary ADLs
25
class III HF
- sx with only minimal exertion
26
class IV HF
- sx at rest
27
common sx of HF
- SOB, esp DOE
- orthopnea
- paroxysmal nocturnal dyspnea
- weight gain
- swelling
- chest pain/ pressure
- fatigue or weakness
- heart palpitations if assoc with arrhythmias
28
triggers for newly dx HF
- acute MI or recent MI
- afib with RVR
- other tachyarrhythmias
29
triggers for decompensation in pts with known HF
- change in diet- increased fluid or salt
| - change in meds- reduced diuretic dose, missed dose, non-compliance
30
common PE findings for HF
- weight gain
- hypoxia
- elevated JVD and + hepatojuglar reflex
- S3 gallop
- pulmonary rales, decreased breath sounds
- pitting edema of LE
31
diagnostic testing for HF
- EKG
- BNP*
- cardiac biomarkers
- CBC and chem 10
- kidney and liver fn
- CXR
- echo for new dx or significant change in chronic dx
32
CXR findings in HF
- blunting of costophrenic angles
- pulmonary vein engorgement- increased interstitial markings
- cephalization
- kerley B lines
- cardiomegaly
33
how do you treat HTN in HF
- BB
- ACE (or ARB if needed)
- if ACE is tolerated then change to ARNI
34
how do you treat ischemic heart disease in HF
- ASA
- BB
- Statin
- revascularization if needed
35
what diuretics do you use in HF
- lasix first
- spironolactone as adjuvant
- budesonide or torsemide if need even more adjunct tx
36
how do you reduce afterload and improve cardiac output for HF
- ACE (or ARB if needed)
| - if ACE is tolerated then switch to ARNI
37
how do you improve cardiac remodeling
- BB
38
what drug improves outcomes for AA with HF
- bidil
| - hydralazine + isosorbide dinitrate
39
what drug reduces hospitalizations in HF
- digoxin
40
stepwise approach for tx of HFrEF
- start on ACE at dx
- start lasix at start of sx
- add BB for all pts
- add sprinonolactone if sx persist
- change from ACE or ARB to ARNI as long as not c/i
- add Bidil for AA with HF class III-IV
- ICD if EF < 35% in class II-III
41
tx of new dx of acute decomp HF
- hospitalize
- IV lasix
- monitor ins, outs, weight, sodium
- rate control with BB or CCB once sx improve, if pt is already on it, or if they require it to tx arrhythmia
- ACEI right away if systolic dysfunction
- monitor K, Mg, kidneys
42
tx for severe hemodynamic compromise HF
- intubation and admit to CCU
- inotropic agents- dobutamine or milrinone
- vasopressors
- mechanical and surgical intervention when severe
43
what is the most common cause of valve disease in developing countries?
- rheumatic fever
44
what is the most common cause of valve disease in developed countries?
- degenerative or inflammatory processes
| - usually valve thickening, calcification, or dysfunction
45
what is the most common cause of acute valve regurg?
- infective endocarditits
46
which type of valvular diseases results in pressure overload?
- stenosis
| - results in ventricular remodeling (LVH)
47
which type of valvular disease results in volume overload?
- regurgitation
- back flow either as valve is closing or leaks when valve is supposed to be closed
- results in eccentric hypertrophy
48
what is the hallmark of the PE for a pt with valvular disease
- murmur
49
imaging to dx valve disease
- transthoracic echo is gold standard
- BNP may be elevated in severe disease
- to dx regurg use doppler echo
50
mitral stenosis
- presumed to have rheumatic heart disease even if no hx
- thickening of valve, posssible calcium deposits
- diastolic murmur
- blood flow from LA to LV during diastole
51
history with MS
- rheumatic fever, prior untreated GABHS
- pregnant pt
- immigrant
- afib
52
symptoms of MS
- usually asymptomatic until mitral valve area is < 1 cm
- new DOE
- afib
- insidious onset cough
- orthopnea, palpitations, fatigue
- sx may be precipitated by pregnancy
53
physical exam findings for MS
- diastolic murmur
- heard best at apex in LL position
- opening snap then S2 sound
- irregular pulse d/t afib
54
treatment for MS
- rate control, anticoag, and conversion to NSR to treat afib
- procedure of choice- percutaneous mitral balloon valvuloplasty
- replacement if stenosis + regurg
- can do maze procedure- ablation to reduce afib recurrence
55
organic mitral regurg causes
- primary abnormality
- degeneration of mitral valve (often with prolapse) most common
- rheumatic heard disease
- infective endocarditis
- trauma
- mitral annular calcifications
56
functional mitral regurg causes
- secondary
| - CAD most common -> ischemia or infacrtion -> LV dilation -> CHF sx (eventually)
57
what is the characteristic sound of mitral regurg
- pansystolic or holosystolic murmur
58
what causes acute mitral regurg
- post MI (2-5 days) -> rapid onset dyspnea and pulm HTN
- infective endocarditis
- indicates the chordae tendinae/ papillary muscle apparatus has ruptured and is a surgical emergency
59
history of mitral regurg
- previous MI or ischemia
- CHF
- h/o infective endocarditis
- cardiomyopathy
60
chronic symptoms of mitral regurg
- may be asymptomatic for life
- dyspnea, SOB
- orthopnea
- pulm edema
- progressive LVD over 6-10 years
61
acute symptoms of mitral regurg
- HF and cardiogenic shock
| - severe pulmonary edema
62
PE findings for mitral regurg
- pansystolic murmur
- best heard at apex
- radiates to axilla
- S3 sound possible
63
prognosis of mitral regurg
- degree of LVD reflects severity and chronicity of regurg
- severe LV volume overload -> LV failure and reduced CO
- can be well tolerated for many years
64
treatment for mitral regurg
- surgery when sx dev or have LV dysfunction
- want surgery before irreversible damage
- surgery indcated when EF < 60% or marked LVD and reduced contractility
- pulm HTN suggests severe MR and requires prompt surgery
- acute MR= emergent surgery
65
mitral valve prolapse
- usually in healthy young women, often asymptomatic
- hear mid-systolic click
- worse with valsalva
66
what is the most common congenital valve lesion
- mitral valve prolapse
67
treatment for mitral valve prolapse
- BB if symptomatic
| - repair/ replacement when severe
68
aortic stenosis
- blocks ejection of blood from LV into aorta
- can be congenital or pathologic
- very common in elderly
- hypertrophied heart muscles require more BF -> relative ischemia -> arrhythmias
69
what is the most common surgical valve lesion in developed countries
- aortic stenosis
70
risk factors for aortic stenosis
- HTN
- hyperlipidemia
- smoking
71
symptoms of aortic stenosis
- CHF like
- syncope with severe obstruction to flow
- onset of sx= severe stenosis
- <1.0 cm of stenosis is severe
72
PE findings for aortic stenosis
- systolic murmur
- crescendo decrescendo murmur
- best heard over aortic area
- radiates to neck
- paradoxical S2 split
- heave or thrill when severe
73
management of aortic stenosis
- no meds found to be effective
- treat coexisting conditions
- repair, implantation, or replacement based on onset of sx and LV dysfunction
74
causes of aortic regurgitation
- congenital
- infective endocarditis
- HTN
- CT diseases- marfan's or ehler's danlos
75
symptoms of chronic aortic regurgitation
- most common presentation- SOB and dyspnea
- palpitations
- elevated LV preload -> increased LVEDV -> LV dysfunction -> CHF
76
acute symptoms of aortic regurg
- sudden onset pulmonary edema
- hypotension
- cardiogenic shock
77
PE findings for aortic regurg
- diastolic decrescendo
- wide pulse pressure on BP when severe
- best heard at right sternal boarder
78
treatment for aortic regurg
- repair/ replacement before irreversible dysfunction
- no pharm tx is effective
- surgery before LVEF < 50% and or/ LVESD > 55 mm
- acute= surgical emergency
- no percutaneous approaches
79
causes of tricuspid stenosis
- rheumatic fever
- carcinoid syndrome
- infective endocarditis
- trauma- CAD, MI
80
symptoms of tricuspid stenosis
- RA enlargement on EKG
| - RHF
81
treatment for tricuspid stenosis
- diuretics for fluid overload
| - bio prosthetic replacement
82
tricuspid regurg
- d/t RVD or RHF
- treat underlying cause
- may have tall pointed P waves
83
pulmonic valve regurgitation causes
- high pressure- pulm HTN
| - low pressure - inherent problem with the valve
84
symptoms of pulmonic valve regurgitation
- RHF
| - loud P2 with early diastolic murmur
85
treatment for pulmonic valve regurg
- correct cause