Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology Week 2 > Chemotherapy (Sweatman) > Flashcards

Chemotherapy (Sweatman) Flashcards

1
Q

2 Main Drugs used for AML? Third?

A

Cytarabine (ARA-C), Daunorubicin, Thioguanine (6-TG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 drugs approved for Hairy Cell Leukemia

A

Cladribine, Pentostatin, IFN-A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

3 most common CLL treatments involve

A

Fludarabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

5 drugs associated with male teratogenicity

A

Cyclo, Doxorubicin, Epirubicin, IFN-A2, MTX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ABVD regimen

A

Doxorubicin, Bleomycin, Vinblastine, Dacarabzine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Adverse effect of Arsenic Trioxide

A

Same RA Syndrome effects + CV effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adverse effects of Cladribine, Pentostatin

A

Potential increased secondary malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse effects of Pegaspargase

A

Bleeding, Glucose Intolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Class X chemo drug

A

Methotrexate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CNS prophylaxis therapy for ALL

A

IT MTX +/- systemic MTX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Consolidation therapy for ALL

A

MTX + Mercaptopurine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Consolidation therapy for ALL often involves

A

RT and 1 or 2 completely diff antimetabolites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Delayed NHL tx effects

A

(1) Sterility; (2) 2nd Maligs; (3) LV dysfunction; (4) MDS and AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Direct antiproliferative effects of IFN

A

Prolong all phases of cell cycle; Induce cellular differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Downside of Arsenic Trioxide vs Tretinoin

A

Black box warning of CV adverse effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drugs for Burkitt

A

Cyclophosphamide + MTX; Vincristine + Doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Drugs susceptible to P-glycoprotein efflux

A

Anthracyclines, MTX, Vinblastine, Oral TKI’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

First line CLL treatment

A

Fludarabine + Cyclophosphamide and/or Rituximab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

General MOA of Cladribine

A

Purine analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How long does functional spermatogonia take?

A

64 days (paternal teratogenicity window)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How to consolidate remission in Hodgkin

A

High-dose therapy and peripheral blood cell progenitor resuce

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How to treat AIHA

A

Corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How to treat Hyperuricemia in CLL

A

Prophylaxis with Allopurinol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Indirect antiproliferative effects of IFN

A

Active CTLs and/or NK; Increase phagocytotic killing; Cytokines, inflammatory response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Major dose-limiting tox of alkylators, like cyclophosphamide

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Metabolism of Tretinoin

A

Hepatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

MOA of ARA-C (Cytarabine)

A

Pyrimidine analog antimetabolite; Inhibits DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

MOA of Arsenic Trioxide (trisenox)

A

Degrades PML-RARA fusion protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

MOA of Asparaginase (Oncaspar)

A

Degrades Asparagine –> Starving protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

MOA of Bendamustine

A

Both an antimetabolite and alkylating agent; DNA crosslinking –> Breakage –> Activates p53 apoptosis

31
Q

MOA of Cyclophosphamide

A

Alkylating agent

32
Q

MOA of Dacarbazine

A

DNA methylator

33
Q

MOA of Daunorubicin

A

Free radical generator, intercalator, topo2 inhibitor

34
Q

MOA of Fludarabine

A

Antimetabolite; DNA strand termination

35
Q

MOA of Ibritumomab (Zevalin)

A

Radio-labeled anti-CD20

36
Q

MOA of Idarubicin

A

DNA interacalation, Topo 2 inh, Free radical gen

37
Q

MOA of Interferon

A

Direct antiproliferative effect + Immunomodulator

38
Q

MOA of Pentostatin

A

Purine analog; ADA inhibitor –> Apoptosis

39
Q

MOA of Thioguanine (6-TG)

A

Purine analog antimetabolite

40
Q

MOA of Tositumomab (Bexxar)

A

Radio-labeled anti-CD20

41
Q

MOA of Tretinoin

A

Disrupts fusion gene –> Differentiation

42
Q

MOA of Vincristine

A

Inh mitotic spindle

43
Q

Most Hodgkin Lymphoma regimens contain

A

(1) Anthracycline; (2) Mitotic spindline inh; (3) Alkylating agent or Bleomycin (a carbazine)

44
Q

Non-TKI drugs for CML

A

Cytarabine, IFN-a2

45
Q

Only successful curative tx of CML

A

Allogeneic BM/stem cell transplant

46
Q

Post-Remission Therapy for AML

A

Intense Cytarabine-based chemo; BM rescue

47
Q

Remission induction therapy for ALL

A

Prednisone + Vincristine + Anthracycline +/- Asparaginase

48
Q

Resistance to Pegaspargase

A

Upregulate Asparagine Synthetase

49
Q

Result of Rituximab binding to CD20 on b cells

A

Complement and ab-dependent cytotoxicity

50
Q

Retinoic Acid Syndrome

A

Fever, dyspnea, weight gain, pulmonary infiltrates, effusions

51
Q

Route for Burkitt chemo

A

Intrathecal (protect brain)

52
Q

Route of Tretinoin

A

Oral

53
Q

TKI’s for CML

A

Imatinib, Dasatinib, Nilotinib

54
Q

Toxicity of 6-TG (Thioguanine)

A

Myelosuppression

55
Q

Toxicity of AML tx regimen

A

Myelosuppression, Cardiotoxicity

56
Q

Toxicity of ARA-C

A

Myelosuppression, Opp infection

57
Q

Toxicity of Dacarabazine

A

Myelosuppression, Hepatotoxicity, 2nd malig

58
Q

Toxicity of Daunorubicin

A

Myelosuppression, Cardiotoxicity

59
Q

Toxicity of Pentostatin

A

Hepato, Pul Edema, Renal, Seizure

60
Q

Toxicity of Tositumomab, Ibritumomab

A

Hematologic: Thrombo-, Neutro-cytopenia, Anemia

61
Q

Toxicity of Tretinoin

A

RA Syndrome; Teratogen

62
Q

Treatment complications of CLL

A

(1) Opp infections; (2) AIHA and/or thrombocytopenia; (3) Hyperuricemia

63
Q

Tx for High Stage NHL

A

R-CHOP: Rituximab + Doxorubicin, Cyclophosphamide, Vincristine, Prednisone

64
Q

Tx for Low Stage NHL

A

COMP: Cyclophosphamide, Vincristine, MTX + Prednisone

65
Q

Tx of APML

A

ATRA, combined with Daunorubicin or Idarubicin +/- cytarabine

66
Q

What is ABVD regiment used for

A

Hodgkin lymphoma

67
Q

What is Bendamustine used to treat

A

CLL

68
Q

What is used in APML pts who can’t tolerate an anthracycline

A

Arsenic Trioxide

69
Q

What is worsened by Fludarabine in CLL

A

AIHA, Thrombocytopenia

70
Q

When and by what are endogenous interferons secreted

A

By leukocytes in response to viral infection or various inducers

71
Q

When to use COMP

A

Low Stage NHL

72
Q

Which are more common: leukemias or lymphomas?

A

Lymphomas (unclear increasing incidence)

73
Q

Why use Rituximab for High Stage B cell NHL

A

DLBCL and Burkitt both express high levels of CD20

Hematology Week 2 (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions