Chemotherapy L1 Flashcards
describe Strain specificity of antibiotics
- Limited spectrum: One organism/disease
- Narrow spectrum: Gram(+) or Gram(-)
- Broad spectrum: Gram(+) and Gram(-)
evolution of peniciclin and how structural changes imrpvoed its efficacy?
bacteriocidal vs bacteriostatic?
describe the MIC for a bacterium
minimal inhibitory concentration (MIC)
lowest conc of a drug that prevents bacterial growth
whats MBC for antibiotics?
minimal bactericidal concentration (MBC)
lowesst conc of a drug that kills a bactrium
For bactericidal drug: MIC is _____ the MBC
or bactericidal drug: MIC is close to the MBC
for bacteriostatic drug: MIC is __________ compared to the MBC
MIC is much smaller than the MBC
describe how you might find out the MIC?
is chloramphenicol bacteriostatic?
yes
describe whats meatn by selective toxicity?
comparison between drugs effects on:
growth of the infecting organism is selectively inhibited or killed without damage to the cells of the host.
whats therapeutic index?
are selective toxicity and therapeutic index alwasy releated?
nooo
Pe-nicillins (bacterial cell wall): -___ selective toxicity & ______ therapeutic index
Pe-nicillins (bacterial cell wall): -high selective toxicity & high therapeutic index
Ionophores (membranes): ____ selectivive toxicity &
_____ therapeutic index
Ionophores (membranes): low selectivi e toxicity &
low therapeutic index
• Aminoglycosides (ribosomes): _______ selective toxicity, ______ therapeutic index.
• Aminoglycosides (ribosomes): high selective toxicity
but low therapeutic index.
