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Medical oncology > Chemotherapy drugs > Flashcards

Chemotherapy drugs Flashcards

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USMLE® Step 1 flashcards
1
Q

Alkylating agent

A

Mustards
Prevent DNA crosslinking by alkylating guanine
E.g cyclophosphamide ifosphamide , decarbazine
Main side effects bladder cystitis (use mesna), N+V

Platinum
Cisplatin
Oxaliplatin
Carboplatin

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2
Q

Anthracycline

A

Antibiotic from streptomyces antibiotic
Non cell cycle specific
Inteferes with topoisomersase 2

Doxorubicin, daunorubicin, mixoxantrine

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3
Q

Bleomycin

A

Induction of DNA strand breaks

IPF

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4
Q

Alkaloids

A

Stop microtubule formation
Vinca alkaloids
Vincristine, vinblastine

Taxanes
Paclitaxel

Camptothecins
Irinotecan
Etoposide
Topoisomerase inhibitor

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5
Q

Antimetabolites

Purine (A,C)
Fludaribine, cytarabine, 6MP

Pyrimidine (TCU)
5FU, capecitabine, gemcitabine

A

Prevents DNA and RNA synthesis by inhibiting nucleoside production

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6
Q

Which chemo has least myelosupression?

A

Vinca alkaloids

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Medical oncology (5 decks)

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