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SB_Medication Side Effects (Pediatrics Royal College 2018) > Chemotherapy Agents > Flashcards

Chemotherapy Agents Flashcards

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1
Q

What are the SE for vincristine?

A
  1. Constipation*
  2. Peripheral neuropathy - foot drop and loss of DTR*
  3. Jaw pain
  4. Shin pain
  5. Hepatotoxicity
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2
Q

What are the SE for vinblastine?

A
  1. Mild neurotoxicity

2. Mucositis

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3
Q

What are the SE for doxorubicin?

A
  1. Severe tissue damage with extravasation
  2. Worsens the effects of XRT
  3. Acute cardiac toxicity i.e. arrhythymias, acute drop in LV function, pericarditis
  4. Chronic cardiomyopathy*
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4
Q

What are the SE for daunomycin?

A
  1. Severe tissue damage with extravasation
  2. Worsens the effects of XRT
  3. Acute cardiac toxicity i.e. arrhythymias, acute drop in LV function, pericarditis
  4. Chronic cardiomyopathy*
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5
Q

What are the SE for cisplatin?

A
  1. Highly emetogenic
  2. Renal toxicity - Mg wasting, azotemiaNeurot
  3. Permanent hearing loss*
  4. Sensory peripheral neuropathy
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6
Q

What are the SE for carboplatin?

A
  1. Permanent hearing loss
  2. Delayed myelosuppression
  3. Hypersensitivity reactions
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7
Q

What are the SE for ifosfamide?

A
  1. Hemorrhagic cystiits*
  2. SIADH
  3. Proximal tubular damage
  4. Neurotoxicity - somnolence disorientation, lethargy
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8
Q

What are the SE for cyclophosphamide?

A
  1. Hemorrhagic cystitis*
  2. SIADH
  3. Cardiac toxicity with high doses
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9
Q

What are the SE for etoposide?

A
  1. Hepatotoxicity
  2. Hypersensitivity reactions
  3. Secondary acute leukemia*
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10
Q

What are the SE for cytarabine?

A
  1. “Ara-C” Syndrome: high fever, malaise, rash, conjunctivitis, myalgias* - relieved by co-administration of corticosteroids
  2. Mucositis
  3. Neurotoxicity
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11
Q

What are the SE for mercaptopurine?

A
  1. Hepatotoxicity

2. Mucositis

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12
Q

What are the SE for thioguanine?

A
  1. Hepatotoxicity

2. Mucositis

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13
Q

What are the SE for methotrexate?

A
  1. Mucositis
  2. Rash
  3. Hepatotoxicity
  4. Nephrotoxicity - avoid by using hydration, alkalinization and leukovorin
  5. Neurotoxicity - acute stroke-like encephalopathy and seizures
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14
Q

What are the SE for imatinib?

A
  1. Nausea
  2. Transient elevation of LFTs
  3. Fatigue
  4. Diarrhea
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15
Q

What are the SE for tretinoin (ATRA)?

A
  1. Teratogenicity*
  2. Pseudotumor cerebri*
  3. Cheilitis
  4. Conjunctivitis
  5. Headache
  6. Xerosis
  7. ATRA syndrome:
    a) Weight gain
    b) Respiratory distress
    c) Serous effusions
    d) Cardiac and renal failure
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16
Q

What are the SE for dactinomycin?

A
  1. Severe tissue damage with extravasation
  2. Hepatic veno-occlusive disease
  3. Mucositis
  4. Can worsen effects of XRT
17
Q

What are the SE for bleomycin?

A
  1. Interstitial pneumonitis that can lead to pulmonary fibrosis*
  2. Dermatologic toxicity
  3. Mucositis
  4. Fever
  5. Hypersensitivity
  6. Raynaud’s phenomenon
18
Q

What are the SE of asparaginase?

A
  1. Allergic reactions
  2. Coagulopathy*
  3. Hepatotoxicity
  4. Pancreatitis*
19
Q

What are the SE of corticosteroids?

A
  1. Weight changes
  2. Mood changes
  3. Hypertension
  4. Myopathy
  5. Avascular necrosis of hips*
  6. Osteopenia
  7. Hyperglycemia
  8. Coagulopathy
  9. Peptic ulcer

SB_Medication Side Effects (Pediatrics Royal College 2018) (2 decks)

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