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OCN Chemo Flashcards > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

Paclitaxel

A

Plant Alkaloid
Breast, pancreatic, lung, H/N
Peripheral neuropathy, milky appearance, skin rash

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2
Q

Dactinomycin

A

Antitumor Antibiotic

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3
Q

Brentuximab Vedotin

A

Monoclonal Antibody-targets CD30
Hodgkin Lymphoma; NHL
Infusion related reactions, peripheral neuropathy, myelosuppression

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4
Q

Doxorubicin

A

Antitumor Antibiotic
Breast; Lymphoma; sarcoma; liver;
cardiomyopathy, vesicant, anthracycline, max cumulative dose of 550mg/m2 (with Cytoxan may be reduced to 450mg/m2)
Testing prior: ECHO/MUGA

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5
Q

Ado-Trastuzumab emtansine

A

Monoclonal Antibody- targets Her 2
Breast
Infusion related reactions, hepatic toxicity (elevated LFT’s), pulmonary toxicity, altered LVEF, thrombocytopenia, bleeding
Testing: ECHO/Muga

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6
Q

Everolimus

A

mTOR inhibitor
Renal; breast; liver
Mucositis, cyp3A interactions

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7
Q

Aldesleukin (IL-2)

A

Biologic Therapy
Melanoma; renal
Capillary leak

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8
Q

Alemtuzumab

A

Monoclonal Antibody-targets CD52
Lymphoma or CLL
Severe lymphodepletion need prophylactic antibiotics.
HSR

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9
Q

Pemetrexed

A

Antimetabolite
lung
Folic acid, Vit B12 replacement
Dex for fluid retention.

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10
Q

Melphalan

A

Alkylating Agent
CLL, MM
High dose- severe mucositis (oral cryotherapy)

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11
Q

Amifostine

A

Not Chemo- chemoprotectant

Hypotension, N/V, Not Chemo

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12
Q

cytarabine

A

Antimetabolite
Leukemia
High dose (greater than 1gm/m2)-cerebellar toxicity and ocular (keratitis), myelosuppression
Testing: Cerebellar assessment

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13
Q

Darbopoietin alfa

A

Growth Factor

Avoid in curable cancers- risk of progression and hyper viscosity (stroke)

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14
Q

Pamidronate

A

Bisphosphonate
Renal toxicity
Used for hypercalcemia and to prevent bone loss, osteonecrosis of the jaw
Testing: Check kidney function prior and make sure do dental work prior

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15
Q

Nelarabine

A

Nucleoside metabolite inhibitor

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16
Q

Ofatumumab

A

Blocks CD20 MAB
Lymphoma
Infusion reaction; Hepatitis reactivation
Testing: Hepatitis panel

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17
Q

Arsenic Trioxide

A

Prolonged QTc, correct K and Mag

Testing: EKG

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18
Q

Asparginase

A 
Asparagine specific activity
ALL
Allergic reaction
Coagulopathies
Pancreatitis
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19
Q

All Trans Retinoic Acid (ATRA)

A

Retinoic acid receptor
AML
Pulmonary syndrome that requires dex

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20
Q

Atezolizumab

A

PDL-1 inhibitor
Urothelial cancer; lung
Immune mediated reactions

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21
Q

Bevacizumab

A

Antiangiogenesis
Colon; ovary; brain; lung
High Bp, headaches, nose bleeds.
Poor wound healing, GI perforation- wait 4 weeks for surgery

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22
Q

Avelumab

A

Monoclonal antibody- Targets PDL-1
urothelial
Infusion related reactions, Immune mediated reactions

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23
Q

Azaciditine

A

Hypomethylating Agent
MDS; AML
In SQ form- skin reaction (2 shots), IV short stability, don’t hold dose for low bld ct

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24
Q

Carmustine

A

Nitrosourea
Brain; NHL; MM
Delayed pulmonary toxicity
Mixed in alcohol

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25
Belinostat
H-DAC inhibitor | Nausea, vomiting, fever, prolonged QT
26
Bendamustine
Alkylating Agent Lymphoma HSR*, rash
27
Inotuzumab Ozogamycin
Monoclonal antibody Targets CD22 ALL Infusion related reactions; LFT abnormalities VOD/SOS, protect from light, no filters, myelosuppression
28
Bleomycin
``` Antitumor Antibiotic Lymphoma; testicular (germ cell) Pulmonary toxicity Fevers HSR* suggest test dose with lymphoma Testing: PFT ```
29
Blinatumomab
Bispecific T cell engager- CD 19>>CD3 ALL Cytokine release syndrome, neurologic symptoms
30
Brentuximab Vedotin
Monoclonal Antibody
31
Bortezomib
Proteosome Inhibitor/ MM Peripheral neuropathy, reactivation of viral infection. Green tea interaction
32
Busulfan
Alkylating Agent Leukemia Seizures in high dose
33
Cabazitaxel
Plant Alkaloid Prostate Low blood counts
34
Irinotecan
Camptothecans GI (colon; rectal and pancreatic); lung Diarrhea - Imodium and cholinergic diarrhea- atropine Testing: check UGT1A1 for metabolism
35
Capecitabine
Antimetabolite GI (colon and rectal); breast Prodrug of 5FU and can be used interchangeably, Hand foot syndrome Prolonged INR
36
Carboplatin
``` Alkylator like (nm) Lung; breast; ovary; endometrial; esophageal; H/N AUC dosing Delayed HSR* (8-10th dose) ```
37
Carmustine | Lomustine
Nitrosourea | Brain
38
Cetuximab
Monoclonal Antibody- Targets EGFR H/N; colon HSR*, acne like rash K-ras mutation doesn’t respond
39
Chlorambucil
Alkylating Agent
40
Cisplatin
Alkylator like (platinum) Lung; testicular (germ cell); esophageal; H/N; cervical N/V; peripheral neuropathy-ototoxicity. Also called CDDP Testing: Renal (check BUN/Cr)
41
Cyclophosphamide
``` Alkylating Agent Breast; lymphoma; non malignancy Cystitis- mesna sometimes used to prevent especially in high dose Void often Secondary malignancies ```
42
Dacarbazine
Burning during peripheral infusion
43
Daratumumab
Anti-CD 38 MAB MM Infusion reaction (first dose can take 10 hours to infuse; Interference with cross-matching and red blood cell antibody screening: Type and screen patients prior to starting treatment. Inform blood banks that a patient has received DARZALEX
44
Dasatinib
Tyrosine kinase inhibitor- BCR/ABL (Philadelphia chromosome) | Pleural effusion
45
Daunorubicin
``` Antitumor Antibiotic anthracycline ALL; AML cardiomyopathy, vesicant, Testing prior: ECHO/MUGA ```
46
Docetaxel
Plant Alkaloid Breast; lung; prostate; ovary; endometrial Tearing, nail changes, fluid retention (give dex); peripheral neuropathy
47
Liposomal Doxorubicin
Antitumor Antibiotic Breast; ovary; endometrial; MM Hand foot rash; use cold to prevent the rash on hands and in mouth (avoid hot in mouth)HSR* Testing: Check ECHO/Muga for LVEF
48
Durvalumab
Monoclonal antibody -Targets PD-L1 Urothelial; lung Immune mediated toxicities
49
Elotuzumab
IVGH inhibitor MM Infusion reaction , peripheral neuropathy, difficulty interpreting IgG Kappa response as the drug interferes with some testing
50
Epirubicin
``` Antitumor Antibiotic/ Breast Cardiac toxicity Vesicant, anthracycline Testing: Check ECHO/Muga for LVEF ```
51
Oxaliplatin
Alkylator like (platinum)/ GI (colon; rectum; pancreatic); lymphoma; esophageal Cold dysesthesia HSR* later doses (8-10) Ox Avoid ice and cold food during infusion Flu vaccine before start of therapy Wig Can cause cold dysestheia
52
Erlotinib
Tyrosine kinase inhibitor (targets EGFR) Lung; liver; pancreatic Acne like Rash Pulmonary (interstitial lung disease)
53
Etoposide
Plant alkaloid Lung; lymphoma; testicular (germ cell) Low blood pressure
54
Fluorouracil (5-FU)
``` Antimetabolite GI (colon; rectum; pancreatic); breast Ice to prevent mucositis Diarrhea Coronary vasospasms, light sensitivity DLT-mucositis ```
55
Floxuridine
Antimetabolite Liver mets Usually given through hepatic artery pump
56
Filgrastim | Sagramostim
Growth factor Bone pain Can be used to mob stem cells To be taken 24 hours after chemo – daily dosage
57
Gemcitabine
Antimetabolite/ Pancreatic; lymphoma; bladder Fever; pleural effusion; low counts with dose mods associated
58
Gemtuzumab ozogamicin
Monoclonal Antibody- Targets CD33/ AML Infusion related reactions, VOD/SOS, myelosuppression
59
Obinutuzumab
Anti CD 20 MAB/ CLL; NHL Infusion reaction, Hepatitis reactivation Testing: Hepatitis panel
60
Imatanib
Tyrosine kinase inhibitor (BCR/ABL- Philadelphia chromosome) | Fluid retention; GI upset
61
Trastuzumab
``` Monoclonal antibody- targets Her 2 Breast; upper GI/lower esophageal Cardiac toxicity; HSR* Testing: ECHO/Muga- check LVEF ```
62
Topotecan
myelosuppression
63
Hydroxyruea
Antimetabolite/ Leukemia; PV; sickle cell Leg ulcers, GI bloating
64
Ibrutinib
BTK inhibitor/ Lymphoma; CLL Increased risk of bleeding especially if on blood thinners, A-Fib, hypertension, leukocytosis
65
Idarubicin
Antitumor antibiotic Leukemia Cardiac/vesicant, anthracycline Testing: ECHO/Muga to check LVEF
66
Ifosfamide
Alkylating Agent/ Sarcoma; ovary; endometrial; lymphoma Cystitis- mesna always Neurologic (coma, hallucinations)
67
Ixazomib
Oral Proteasome inhibitor | Peripheral neuropathy, nausea
68
Ixabepilone
Mitotic inhibitor (plant alkaloid)/ Breast Peripheral neuropathy
69
Pembrolizumab
PDL-1 inhibitor | Immune mediated reactions
70
Palifermin
Keratinocyte growth | To rebuild mucosa to prevent mucositis
71
Lapatinib
TKI | Prolonged QTc
72
Olaratumab
Monoclonal Antibody- targets platelet derived growth factor alpha Sarcoma Infusion related reactions, lymphopenia, neutropenia, thrombocytopenia, hyperglycemia, elevated aPTT, hypokalemia, and hypophosphatemia.
73
Lenalidomide
Immunomodulator MM Teratatogenic (part of a REMS program to assure no pregnancy r/t issues), rash, increased risk of blood clots
74
Leucovorin
Synergistic with 5FU and a rescue for high dose methotrexate, Not Chemo
75
Liposomal Daunorubicin + cytarabine
Combination of an antitumor antibiotic and antimetabolite/ MDS; AML Purple in color, Bleeding, febrile neutropenia, rash, edema, nausea/vomiting, mucositis, diarrhea, constipation, musculoskeletal pain, fatigue, abdominal pain, dyspnea, headache, cough, decreased appetite, arrhythmia, pneumonia, sleep disorders. Testing: ECHO/Muga to check LVEF
76
Mechlorethamine
Infertility, vesicant
77
Mesna
Binds to metabolite of ifosphamide and cyclophosphamide
78
Methotrexate
Antimetabolite Lymphoma; breast; non malignancy High dose renal toxic and need leucovorin rescue Give sodium bicarbonate to maintain kidney function
79
Mitomycin
Antitumor antibiotic/ Rectal cancer IV; bladder intrabladder
80
Mitoxantrone
Anti tumor antibiotic/ Lymphoma; breast Cardiac, blue
81
Plerixafor
CXCR4 inhibitor/ Stem cell mobilization Abd cramping Used to mobilize stem cells for BMT
82
Vinorelbine
Plant alkaloid/ Breast; lung; sarcoma Vesicant, give through side arm of running IV, severe pain at tumor site
83
Necitumab
Monoclonal Antibody- Targets EGFR | Infusion related reaction; Skin related reactions (EGFR-like); low mag, low phos, low calcium
84
Oprelvekin
Platelet growth factor- capillary leak
85
Sorafenib
Multikinase inhibitor | Rash, long eyelashes
86
Mechlorethamine
Sterility
87
Nivolumab
Monoclonal antibody (PD1 inhibitor)/ Lung; Hodgkin; many Immune mediated effects
88
Vincristine
``` Plant alkaloid Lymphoma; ALL Peripheral neuropathy Cap at 2mg Jaw pain ```
89
Pamidronate
bisphophonate | Osteonecrosis of the jaw, elevated creatinine
90
Panitumumab
EGFR antagonist/ Colon cancer Acne like rash, nail changes, Magnesium depletion
91
Pertuzumab
Monoclonal antibody against HER 2/ Breast cancer Check LFTs and ECHO/Muga- LVEF
92
Pomolidomide
Immune modulator/ MM REMS program for reproductive toxicity; Rash, somnolence, myelosuppression
93
Rituximab
MAB- targets CD20/ Lymphoma; CLL; autoimmune HSR* Reactivation of Hep
94
Temozolamide
Alkylating agent/ Brain tumor Immune suppression – need to be on septra
95
Thalidomide
Immune modulator MM Peripheral neuropathy; constipation; STEPS (for reproductive issues)
96
Trabectedin
Alkylating agent/ Sarcoma 24 hour infusion (home pump); vesicant, nausea, elevated LFT’s and CPK (rhabdomyolysis), capillary leak syndrome
97
Vinblastine
Plant alkaloid/ Hodgkin disesae Myelosuppressive Peripheral neuropathy, jaw pain, vesicant
98
Venetoclax
BCL-2 inhibitor/ CLL; AML Tumor lysis syndrome, myelosuppression, drug-drug interactions
99
Y90 Ibritumomab tiuxetan
Emits radiation out of the skin and thus will need to be away from family for about a week or so. Infused hot dose in lead lined room.
100
Zolodrenic acid
bisphosphonate Used for breast cancer now to prevent bone mets Used to prevent skeletal related events (fractures) Renal toxic, osteonecrosis of the jaw
101
Supportive drugs: peripheral neuropathy
``` Duloxetine Gabapentin Pregabalin Amitriptyline Venlafaxine ```
102
Supportive drugs: Nausea
Metoclopramide
103
Supportive drugs: Antidepression
``` Mirtazapine Venlafaxine Duloxetine Amitriptyline Citalopram ```
104
Xgeva
To prevent skeletal fractures; low calcium is a risk AE: peripheral neuropathy
105
Leuprolide
Blocks gonadotropin releasing hormone for breast and prostate cancer (can be used to preserve fertility- chemical menopause during treatment) Give as 2 injections in the buttocks. Side effects – hormonal symptoms and higher risk for blood clot
106
Goserelin
Blocks gonadotropin releasing hormone for breast and prostate cancer (can be used to preserve fertility- chemical menopause during treatment) Give as large injection in the abdomen (pellet). Side effects – hormonal symptoms and higher risk for blood clot
107
Dexrazoxane
Protective agent for the heart (zinecard) for anthracyclines; treatment for anthracycline extravasation (totect)
108
Tx whale or flare and pain at injection site Of doxorubicin and epirubicin
Dex-razoxane
109
Interleukin-2
Mets melanoma | RCC
110
Prochlorperazine Side effect
Extrapyramidal reaction - shuffling gait - loss of balance - tremors - difficulty speaking or swallowing - twitching Tx for n/v caused by emergencies chemo
111
Flare reaction At iV site
May cause itching, blotchiness, or streak along or next to the vein receiving infusion -without swelling or pain
112
Monoclonal antibody -mab Interfere with ?
Interfere with cell membrane bound targets by Blocking ligand receptor activation and Immune modulation This preventing rapid growth of cancer cell
113
Bevacizumab
SE: Hypertension Proteinuria
114
Oral contraceptive >5 years can prevent which cancer?
In prevention of ovarian cancer families with lynch syndrome, not genetically at risk for breast cancer Lynch syndrome - heredity non-polyploid colorectal cancer (HNPCC) is the most common cause of heredity colon rectal cancer before 59
115
Cancer patient Experiencing from erectile dysfunction What is the Tx
po Phosphodiesterase type 5 inhibitors Have been a recommended practice
116
Hospice patient experiencing delirium What med?
Haloperidol
117
Doxorubicin SE
Fever- ruby red Extravasation- tissue necrosis is usually evidence 2-3w after extravasation
118
Intrathecal safe chemo
Methotrexate | Cytarabine
119
-nib Regotafenib Anti VEGFR Cororectal ca Hcc
-po same time Liver problems Hypertension Bleeding
120
SCT
Relapse and sinusoidal obstruction syndrome is most common life threatening complication

OCN Chemo Flashcards (7 decks)

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