Chemotherapy

Question 1

Main groups

Answer 1

Alkylating (Cyclophosphamide, Platin)
Topoisomerase inhib (Anthracyclines, Irinotecan, Eposonid
Mitotic inhibitors
Antimetabolites

Question 2

Alkylating

2 groups with Ind and SE

Answer 2

Cyclophosphamide for ALL with hemorrhagic cystitis

Platin derivates for Ovarian Lung Urothel with Neuro/Nephro/Ototoxicity

Question 3

Mitotic poisons 2 groups Ind SE

Answer 3

Vinca alkaloids (Vincristin/Vinblastin) for Lymphomas with neurotoxicity

Taxanes (Docetaxel/Paclitaxel) for mamma/ovary/pancreas/stomach with myelotoxicity and lung fibrosis

Question 4

Topoisomerase inhibitors 3 groups Ind SE

Answer 4

Anthracyclines
Doxerubicin and others rubicins for Acute Leucemias and ovarian with cardio toxicity

Topoisomerase1 inhibitors
Irinotecan for ovarian and CRC with myelotoxicity

Topoisomerase2 inhibitors
Etoposid for bronchial ovarian testicular lymphomas with myelotoxicity

Question 5

Antimetabolites 3 groups ind se

Answer 5

Folic acid antagonists
Methotrexate for immunosuppression and osteosarcomas with myelotoxicity hepatotoxicity mucositis

Pyrimidine antagonists
5-Fluorouracil or capecitabin for mamma/ovarian/prostate/stomach with myelotoxicity

Purine antagonists
Azathioprine for immunosuppression and Avute leukaemia with KI with allopurinol

Question 6

Which chemotherapeutics in pregnancy?

Answer 6

Anthracyclines (Doxerubicin) and taxanes (docetaxel)