Chemotherapy

Question 1

Interferes with DNA synthesis

Answer 1

Methotrexate

Question 2

Inhibits folate to be taken up by the cell

Answer 2

Methotrexate

Question 3

Has a high affinity for Dihydrofolate

Answer 3

Methotrexate

Question 4

Inhibits FH2 from being hydrolyzed into FH4

Answer 4

Methotrexate

Question 5

No nucleotide production = no cell replication

Answer 5

Methotrexate

Question 6

Cytotoxic antibiotic- interferes with DNA replication

Answer 6

Doxyrubicin

Question 7

stabilizes DNA- Topoisomerase complex

Answer 7

Doxyrubicin

Question 8

Normally relaxes DNA Supercoil and breaks the strand apart for replication

Answer 8

Topoisomerase II

Question 9

Drug that prevents DNA strands from being put back together

Answer 9

Doxyrubicin

Question 10

Alkylating Agent

Answer 10

Cyclophosphamide

Question 11

Prevents DNA Replication

Answer 11

Cyclophosphamide

and

Doxorubicin

Question 12

Attaches an alkyl groups to guanine

Answer 12

Cyclophosphamide

Question 13

crosslink via covalent bond causes DNA to supercoil

Answer 13

Cyclophosphamide

Question 14

Topoisomerase unable to break apart DNA

Answer 14

Cyclophosphamide

Question 15

Interferes with mitosis

Answer 15

Vincristine

Question 16

binds to microtubule dimers which prevents their polymerization

Answer 16

Vincristine

Question 17

Arrests cell in metaphase

Answer 17

Vincristine

Question 18

prevents spindle formation

Answer 18

Vincristine

Question 19

What do microtubules do

Answer 19

polymerize into long strands that pulls copies of chromosomes to opposite sides of cell

Question 20

Hormone Therapy

Answer 20

Tamoxifen

Question 21

Hormone therapy to treat estrogen positive breast cancer

Answer 21

Tamoxifen

Question 22

__________ drug is an _________ to the estrogen receptor

Answer 22

Tamoxifen, Antagonist

Question 23

Causes a conformational change that inhibits estrogen from binding to its receptor

Answer 23

Tamoxifen

Question 24

Monocloanal antibodies

Answer 24

Cetuximab, Bevacixumab (Avastin)

Question 25

What do monoclonal antibodies do?

Answer 25

Block Growth Signals

Question 26

What dod mutated growth factor receptors do?

Answer 26

give a signal to proliferate even without growth factor bound

Question 27

Stops hyperproliferation by binding to mutated growth factor receptors and preventing downstream signaling

Answer 27

Cetuximab

Question 28

drug will not work if hyper proliferation is caused by downstream signaling and not the mutated receptor itself

Answer 28

Cetuximab

Question 29

Monoclonal antibody that blocks angiogenesis

Answer 29

Bevacixumab (Avastin)

Question 30

binds to VEGF-A which inhibits growth factor binding

Answer 30

Bevacixumab (Avastin)

Question 31

Tyrosine Kinase Inhibitor

Answer 31

Gleevec (Imantinib)

Question 32

inhibits an Oncogene

Answer 32

Gleevec (Imantinib)

Question 33

Philadelphia chromosome translocation

Answer 33

BCR- Ab1 - chromosome 22 and 9

Question 34

BCR- Ab1 translocation causes what cancer? How?

Answer 34

Chronic Myelogeneous Leukemia - mutated protein always has Tyrosine Kinase On causing continued proliferation

Question 35

Prevents phosphorylation of the tyrosine kinase target which inhibits downstream proliferation

Answer 35

Gleevec (Imantinib)

Question 36

Normal tyrosine kinase function

Answer 36

enzyme that removes a phosphate from ATP and attaches it to a tyrosine amino acid on a protein

Question 37

What does the addition of a kinase to a protein generally do?

Answer 37

Signaling a downstream cascade