Chemo + Side Effects Flashcards
Everolimus
Targeted
Afinitor
Mucositis
BG, lipids
CYP
Sorafenib
Targeted
Nexavar
Diarrhea
Hand-foot syndrome, BP
CYP
Temsirolimus
Targeted
Torisel
Oral, fatigue,
BG, lipids, liver, anemia
CYP
Oxaliplatin
Chemo - alkylating agent
Eloxatin
N/V, fatigue
peripheral neuropathy (cold), anemia, rash
Aromatase inhibitors SE + 3 examples
Bone loss, joint pain, cardiac
Ex: anastrazole, letrozole, exemestane
Rapamune
Immunosuppressant, Sirolimus
Lipids, renal, caution in tx pts
Cetuximab
Biotherapy - monoclonal antibody (EGFR inhibitor)
Erbitux
Diarrhea, fatigue
Rash, low Mg
CYP
Erlotinib
Biotherapy - EGFR inhibitor (TKI)
Tarceva
Diarrhea, fatigue
Rash, liver, lung, renal, GI perforation
CYP
Cyclophosphamide
Chemo - Alkylating agent
Cytoxan
N/v
Less common: diarrhea, oral
Anemia, renal, cardiac, 2nd cancers
Extra hydration
CYP
Melphalan
Chemo - alkylating agent
Alkeran
N/v, diarrhea, oral
Anemia, renal
Irontecan
Chemo - Topoisomerase inhibitor
Camptosar
Severe diarrhea (I run to the can), n/v
anemia, rash
Bowel perforation
CYP
Bortezomib
Targeted
Velcade
N/v, diarrhea, fatigue
Peripheral neuropathy, anemia
Avoid Vitamin C, Vitamin K, green tea
CYP
Pemetrexed
Chemo - Antimetabolite (folate antagonist)
Alimta
fatigue, nausea, anorexia
Folic acid 400-1000 mcg orally
1 week prior to first dose - 3 weeks after last dose
Vitamin B12 (1000 ug) IM injections
1 week prior to first dose - given every 3 cycles
CYP
Regorafenib
Targeted
Stivarga
Fatigue, diarrhea, anorexia, oral
Hand foot syndrome, liver
Take in morning with low fat meal (<8 g fat)
CYP
Methotrexate
Chemo - antimetabolite (folate antagonist)
Folex / Rheumatrex
diarrhea, n/v, oral
rash, anemia, liver
Avoid folic acid supplements
CYP
Bexarotene
Targeted - Retinoid
Targretin
Limit Vitamin A to <1500 IU
CYP
Nilotinib
Targeted - TKI
Tasigna
anemia, electrolytes
contains lactose
take on empty stomach
CYP
Deferasirox
Biotherapy - iron chelator
Exjade
diarrhea, n/v
rash
contains lactose
Mercaptopurine
Chemo - Antimetabolite
Purinethol
Anemia
Avoid dairy
Zoledronic Acid
Biotherapy - Biphosphonate
Zometa
n/v, fatigue
anemia
Bone density: D, calcium, exercise
osteonecrosis of the jaw
Anastrazole
Hormonal - Aromatase Inhibitor (AI)
Arimidex
cholesterol
Bone density: D, calcium, exercise
CYP
Letrozole
Hormonal - Aromatase inhibitor (AI)
Femara
choesterol
Bone density: D, calcium, exercise
CYP
Exemestane
Hormonal therapy - Aromatase inhibitor (AI)
Aromasin
Bone density: D, calcium, exercise
CYP
Cisplatin
Chemo - Alkylating agent
Platinol
n/v
renal, peripheral neuropathy, anemia, rash
monitor electrolytes (low Mg)
Extra hydration
Panitumumab
Targeted therapy - EGFR inhibitor)
Vectibix
monitor electrolytes (low Mg and calcium)
Carboplatin
Chemo - Alkylating agent
Paraplatin
Monitor electrolytes (low Mg and calcium)
Azacitidine
Chemo - antimetabolite
Vidaza
anemia, liver, renal
(low K)
Ado-trastuzumab emtansine
Drug conjugate (chemo + targeted)
Kadcyla
low K
Denosumab
Biotherapy - monocolonal antibody (RANKLR inhibitor)
Xgeva, Prolia
low Ca
osteonecrosis of the jaw
Procarbazine
Chemo - alkylating agent
Matulane
Avoid tyramine and alcohol
CYP
Vinca alkaloids
Vincristine
Vinblastine
Vinorelbine
Chemotherapies - mitotonic inhibitors
Jaw pain
CYP
Doxorubicin
Chemo - antitumor antibiotic
Adriamycin
oral
CYP
5-Fluorouracil
Chemo - antimetabolite
Adrucil
Diarrhea, oral
Anemia, cardiac
Add B6, avoid folic acid
Bowel perforation
