Chemo Pharm Flashcards
cyclophosphamide
alkylating agent broad application (burkitts, breast, ovarian, non hodgkin) AE: hemorrhagic cystitis, give IV hydration at high dose
mechlorethamine
alkylating agent
N
topical for cutaneous T cell lymphoma
melphalan
alkylating agent
IV
multiple myeloma (plus dexamethasone)
chlorambucil
alkylating agent
oral
chronic lymphoblastic leukemia
carmustine
alkylating agent
for glioma
AE: myelosuppression
streptozocin
alkylating agent
pancreatic islet cell carcinoma, carcinoid tumors
AE: nausea, renal, hepatotoxicity
thiotepa
alkylating agent
AE: coma, seizure
hematological malignancy with transplant pt
busulfan
alkylating agent
AE: pulmonary fibrosis, hepatic venocclusive disease
given with anticonvulsant
for CML
procarbazine
alkylating agent resistance when cancer cells express MGMT AE secondary cancer part of MOPP for hodgkin part of PVC for glioma
dacarbazine
alkylating agent
for hodgkin
AE: myelosuppession, vomit, nausea
bendamustine
alkylating agent
CLL and non hodgkin
AE: myelosuppression and mucositis
cisplatin
alkylating agent, platinum analogs
requires chloride diuresis and IV hydration
reverse with aluminum
AE: nephrotoxic, ototoxic, nausea, vomit, neuropathy, anemia, AML
testicular cancer, ovary
carboplatin
alkylating agent, platinum analogs
AE: myelosuppression
ovarian, small cell lung
oxaliplatin
alkylating agent, platinum analogs
neurotoxic, leukemia, pulmonary fibrosis
for colorectal and gastric cancer
methotrexate
antimetabolite
folic acid analog
for breast, head, neck, osteosarcoma, CNS lymphoma, non hodgkin, bladder and choriocarcinoma
pemetrexed
antimetabolite S phase activity AE Myelosuppression, skin rash, diarrhea fatigue, hand foot syndrome for mesothelioma, NSCLC supplement with B12 and folic acid
pralatrexate
antimetabolite
AE: myelosuppression, rash, diarrhea
supplement with B12 and folic acid
for periferal T cell lymphoma
5FU
animetabolite
for colorectal cancer, breast, stomach, pancreas, esophagus, liver
capecitabine
animetabolite
5fu prodrug: metastatic breast, colon cancer,
TAS102
animetabolite
colorectal cancer
cytarabine
S phase animetabolite
AML and non hodgkin
gemcitabine
animetabolite
pancreatic, NSCLC, bladder, ovarian, sarcoma, nonhodgkin
