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Heme/Lymph > Chemo Pharm > Flashcards

Chemo Pharm Flashcards

1
Q

cyclophosphamide

A 
alkylating agent
broad application (burkitts, breast, ovarian, non hodgkin) AE: hemorrhagic cystitis, give IV hydration at high dose
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2
Q

mechlorethamine

A

alkylating agent
N
topical for cutaneous T cell lymphoma

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3
Q

melphalan

A

alkylating agent
IV
multiple myeloma (plus dexamethasone)

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4
Q

chlorambucil

A

alkylating agent
oral
chronic lymphoblastic leukemia

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5
Q

carmustine

A

alkylating agent
for glioma
AE: myelosuppression

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6
Q

streptozocin

A

alkylating agent
pancreatic islet cell carcinoma, carcinoid tumors
AE: nausea, renal, hepatotoxicity

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7
Q

thiotepa

A

alkylating agent
AE: coma, seizure
hematological malignancy with transplant pt

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8
Q

busulfan

A

alkylating agent
AE: pulmonary fibrosis, hepatic venocclusive disease
given with anticonvulsant
for CML

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9
Q

procarbazine

A 
alkylating agent
resistance when cancer cells express MGMT
AE secondary cancer
part of MOPP for hodgkin
part of PVC for glioma
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10
Q

dacarbazine

A

alkylating agent
for hodgkin
AE: myelosuppession, vomit, nausea

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11
Q

bendamustine

A

alkylating agent
CLL and non hodgkin
AE: myelosuppression and mucositis

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12
Q

cisplatin

A

alkylating agent, platinum analogs
requires chloride diuresis and IV hydration
reverse with aluminum
AE: nephrotoxic, ototoxic, nausea, vomit, neuropathy, anemia, AML
testicular cancer, ovary

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13
Q

carboplatin

A

alkylating agent, platinum analogs
AE: myelosuppression
ovarian, small cell lung

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14
Q

oxaliplatin

A

alkylating agent, platinum analogs
neurotoxic, leukemia, pulmonary fibrosis
for colorectal and gastric cancer

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15
Q

methotrexate

A

antimetabolite
folic acid analog
for breast, head, neck, osteosarcoma, CNS lymphoma, non hodgkin, bladder and choriocarcinoma

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16
Q

pemetrexed

A 
antimetabolite
S phase activity
AE Myelosuppression, skin rash, diarrhea fatigue, hand foot syndrome
for mesothelioma, NSCLC
supplement with B12 and folic acid
17
Q

pralatrexate

A

antimetabolite
AE: myelosuppression, rash, diarrhea
supplement with B12 and folic acid
for periferal T cell lymphoma

18
Q

5FU

A

animetabolite

for colorectal cancer, breast, stomach, pancreas, esophagus, liver

19
Q

capecitabine

A

animetabolite

5fu prodrug: metastatic breast, colon cancer,

20
Q

TAS102

A

animetabolite

colorectal cancer

21
Q

cytarabine

A

S phase animetabolite

AML and non hodgkin

22
Q

gemcitabine

A

animetabolite

pancreatic, NSCLC, bladder, ovarian, sarcoma, nonhodgkin

Heme/Lymph (2 decks)

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