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MPJE + NAPLEX 2023 PREP > chemo man > Flashcards

chemo man Flashcards

1
Q

vincristine / vinorelbine

A

neurotoxicity

paralysis

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2
Q

cisplatin

A

ototoxicity

neurotoxicity

light sense

electrolyte decrease

nephrotoxic

THUS give mannitol or amofostine and hydration

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3
Q

daunorubicin & doxorubicin

A

cardiotoxicity, CHF –> give dexrazoxane (Zinecard)

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4
Q

cyclophosphamide

A

cardiac effects

dose limiting hemorrhagic cystitis –> give MESNA

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5
Q

vincristine

A

SIADH (decreases urine // body retains water)

SIADH = syndrome of inappropriate antidiuretic hormone secretion

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6
Q

what causes alopecia?

A

vinorelbine

cyclophosphamide

ifosfamide

topatecan

paclitaxel

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7
Q

irinotecan

A

hepatotoxicity

cholinergic –> diarrhea:
-early onset: give 1 mg atropine
-late onset: give imodium

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8
Q

MTX

A

myelosuppression

mucositis

pulmonary fibrosis

*leucoverin rescue

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9
Q

5-FU

A

Fluorouracil

mucositis

hand-foot mouth syndrome

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10
Q

cytarabine (Ara-C)

A

CNS

neurotoxicity

visual and personality changes

*give steroids

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11
Q

bleomycin and busulfan

A

pulmonary fibrosis (CXR)

hyperpigmentation

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12
Q

streptozocin

A

pancreatic damage –> IDDM

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13
Q

carmustine

A

renal / hepatic toxicity

pulmonary fibrosis (CXR)

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14
Q

ifosfamide

A

altered mental status

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15
Q

vincristine, vinblastine, vinorelbine

A

dose limiting peripheral neuropathy

vinCristine: CNS & constipation

vinBlastine: bone marrow suppression

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16
Q

paclitaxel

A

avoid PVC tubing

hypersensitivity reaction

*pretreat w/ antiemetics, Benadryl, & dexamethasone

17
Q

docetaxel

A

fluid retention / pulmonary edema

*pretreat w/ dexamethasone

18
Q

agents that cause the most cardiotoxicity

A

doxorubicin

daunorubicin

idarubicin

epirubicin

mitoxantrone

MPJE + NAPLEX 2023 PREP (16 decks)

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