ANTIDOTES - PNN Flashcards
apap
N-acetylcysteine - acetadote (IV), Cetylev (oral)
anticholinergics / antihistamines
physostigmine (antilirium)
organophosphates / pesticides / malathion
atropine or pralidoxime (protopam, 2-pam)
cholinergics
atropine or pralidoxime (protopam, 2-pam)
atropine + pralidoxime (ATNAA, duodote)
cyanide
cyanide antidote kit, cyanokit (hydroxocobalamin)
hypoglycemic agents
glucagon
octreotide (sandostatin) also used for sulfonylureas
beta blockers
glucagon
calcium channel blockers
calcium chloride
and/or calcium glucagon
digitalis
dig immune fab
theophylline
beta blockers
serotonin syndrome
cyproheptadine
dystonic reaction
benztropine (cogentin) or diphenhydramine (benadryl)
NMS (neuroleptic malignant syndrome)
bromocriptine, dantrolene
ethylene glycol (antifreeze)
fomepizole (antizol), ethanol 10%
methanol (wood alcohol)
fomepizole (antizol), ethanol 10%
lead
dimercaprol (BAL), EDTA-Calcium, DMSA (succimer)
BAL in Oil = Dimercaprol
arsenic
dimercaprol (BAL), or DMSA
BAL in Oil = Dimercaprol
heavy metals
dimercaprol or penicillamine
BAL in Oil = Dimercaprol
gold
dimercaprol
BAL in Oil = Dimercaprol
mercury
D-penicillamine
copper (wilson dz)
penicillamine
iron (hemachromatosis disease)
deferoxamine (desferal)
heparin
protamine sulfate
[ most of the times holding the next one or two doses will correct the situation and antidotes are rarely used ]
warfarin
vitamin K (phytondione, mephyton)
[ most of the times holding the next one or two doses will correct the situation and antidotes are rarely used ]
benzodiazepines / zolpidem
flumazenil (romazicon)
opiates
naloxone (narcan)
lithium
no antidote; correct Na+, supportive care, HD
barbiturates
no antidote, use charcoal if early and alkalinize urine with NaHCO3, supportive care
TCAs
NaHCO3
dabigatran
idarucizumab / praxbind
rocuronium or vecuronium
sugammadex (bridion)
off-label use of acetylcysteine
prevention of contrast-induced nephropathy