Chemo Drugs not in deck

Question 1

mechlorethamine

Answer 1

nitrogen mustard
—rapid IV or topical
—incr risk of 2° malig so rarely used
—decendents incl: melphalan, ifosphamide, chlorambucil

Question 2

aprepitant

Answer 2

anti-emetic

—blocks substance P; $$

Question 3

ondansetron

Answer 3

—| 5-HT(3)

Question 4

leucovorin

Answer 4

1 RESCUE) straight up methylene FH4

2 ADJUNCT) potentiates 5-FU by stabilizing binding of FdUMP to thymidylate synthase

Question 5

pathophys of nausea

Answer 5

enterochromaffin gut cells —> 5-HT receptor —> X

—vagal response to emetic chemo agents

Question 6

which cancers commonly = 2° malig

Answer 6

AML, MDS

Question 7

etoposide

• class?
• mech?

Answer 7

epidophyllotoxin (V-16 is another)

—inhibs II —> DNA breaks —> apop

Question 8

bortezomib (velcade); carfilzomib

Answer 8

• proteosomal inhib -> inhib prot degrad -> unfolded-prot-stress-resp -> apop
• (similar to heat shock resp)

Question 9

just name 3 IMIDs

Answer 9

thalidomide, lenalidomide, pomalidomide

—mech unknown

Question 10

IL-2

Answer 10

stims anti-tumor imm resp via GFR-family

Question 11

rituximab

• indication
• MOAs
• descendents

Answer 11

mab against CD20 on B’s
—give w/ R-CHOP for NHL pts
—MOAS: 1) Fx mediated phag, 2) complement cytotoxicity, 3) apop induction

descendants: tiuxetan, tositumomab

Question 12

5-azacytidine

Answer 12

epigenetic target
—turns off methylation which increases expression of tumor suppressor genes
—mild SEs
—AML/MDS