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level 1 facts worth revisiting > chemo drugs and oncogenes > Flashcards

chemo drugs and oncogenes Flashcards

1
Q

list the alkylating agents under the 6 subclasses

A

bis(chlorethyl)amines

  • cyclophosphomide
  • mechlorethamine
  • mephalan
  • chlorambucil

aziridines

  • thiotepa

nitrosureas

  • carmustine
  • streptozocin

alkylsulfonate

  • busulfan

non-classic

  • procarbazine
  • dacarbazine
  • bendamustin

platinum analogues

  • cisplatin
  • carboplatin
  • oxaliplatin
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2
Q

list the antimetabolites under their 4 subheadings

A

antifolates

  • MTX
  • premetrexed
  • pralatrexate

fluoropyrimidines

  • 5-FU
  • capecitiabine
  • TAS-102

deoxycytidine analogs

  • cytarabine
  • gematabine

purine antagonist

  • 6-MP
  • 6-TG

other

  • fludarabine
  • cladribine
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3
Q

list the “natural products” chemo agents under the 4 headings

A

vinca alkaloids

  • vinblastin
  • vincristine
  • vinorelbine

taxanes + anti-microtubule

  • paclitaxel
  • docetaxel
  • cabazitaxel
  • ixabepilone
  • eribulin

epipodophyllotoxin

  • etoposide

camptothecins

  • topotecan
  • irinotecan
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4
Q

list the anti-tumor antibiotics

A

anthracyclines

  • doxorubicin
  • daunorubicin
  • idarubicin
  • epirubicin
  • mitoxantrane

iron chelating

  • dexrazoxane
  • actinomycin
  • bleomycin
  • mitomycin
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5
Q

which chemo drugs are tyrosine kinase inhibitors

A

imatinib

dasatinib

nilotinib

bosotinib

pollatinib

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6
Q

list the growth factor inhibior chemo drugs

A

cetuximab

panitumumab

ecitumumab

erlotinib

afatinib

usimertinib

bevalizumab

ziu-aflibercet

rumucirumab

surafenib

sunitinib

azopanib

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7
Q

which chemo drugs act as immune checkpoint inhibitors

A

PD-L1 inhibitors

  • alezolizumab
  • avelumab
  • dorvalumab

PD-1 inhibitors

  • nivolumab
  • dembrolizumab
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8
Q

CA associated w KRAS

A

colorectal CA and non-small cell lung CA

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9
Q

RAS

proto-oncogene or tumor suppressor gene?

associated CA?

A
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10
Q

MYC

proto-oncogene or tumor suppressor gene?

associated CA?

A
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11
Q

EGFR and HER2

proto-oncogene or tumor suppressor gene?

associated CA?

A
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12
Q

ABL

proto-oncogene or tumor suppressor gene?

associated CA?

A
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13
Q

BRAF

proto-oncogene or tumor suppressor gene?

associated CA?

A
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14
Q

APC / beta catenin

proto-oncogene or tumor suppressor gene?

associated CA?

A
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15
Q

TP53 vs RB vs VHL

proto-oncogene or tumor suppressor gene?

associated CA?

A
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level 1 facts worth revisiting (6 decks)

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