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Lectures > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

1
Q

Alkylating agents

A 
Bendamustine 
Busulfan
Carboplatin
Carmustine 
Chlorambucil
Cisplatin 
Cyclophosphamide 
Decarbazine (DTIC)
Ifosfamide 
Lomustine
Melphalan 
Mechlorethamine 
Oxiplatin 
Procarbazine 
Temozolomide
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2
Q

Antibiotics

A

Bleomycin

Dactinomycin

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3
Q

Topo II Inhibitors

A 
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Etoposide 
Mitoxantrone
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4
Q

Antibodies

A 
Alemtuzumab - Anti CD52
Bevacuzimab - Anti-VGEF
Cetuximab - Anti-EGFR
Rituximab - Anti-CD20
Trastuzumab - Anti-Her2/neu
Ipilimumab - Anti-CTLA4
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5
Q

Antimetabolites

A 
Decitabine + azacitidine - nucleosides + hypomethylate DNA at low doses 
Cytarabine - pyrimidine analog 
Fludarabine - purine analog 
Flurouracil - pyrimidine analog 
Gemcitabine - pyrimidine analog 
Mercaptopurine - purine analog 
Cladribine - purine analog
Thioguanine - purine analog 
Methotrexate - antifolate 
Pentostatin - ADA inhibitor 
Pemetrexed - antifolate, targets additional enzymes of purine and pyrimidine synthesis
  • all cause myelosuppression
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6
Q

Antimicrotubular

A 
Docetaxel 
Ixabepilone 
Paclitaxel
Vinblastine 
Vincristine

*all cause myelosuppression

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7
Q

Growth factors

A

Erythropoeitin - clotting if hgb >10
Filgrastim - fevers, chills, bone pain
G-CSF or GM-CSF - fevers, chills, bone pain
Sargramostim - fever

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8
Q

HDAC inhibitor

A

Romidepsin - myelosuppression

Vorinostat - nausea, myelosuppression, clotting

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9
Q

Aromatase antagonists

A 
Anastrazole = aromatase inhibitor --> bone loss + fatigue
Exemestane = aromatase inhibitor --> bone loss + fatigue
Letrozole = aromatase antagonist --> bone loss,fatigue
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10
Q

Androgen antagonists

A 
Bicalutamide = androgen receptor antagonist --> bone loss 
Flutamide = androgen receptor antagonist --> nausea
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11
Q

Estrogen/progresterone antagonists

A 
DES = estrogen receptor antagonist --> bone loss + thrombosis 
Megestrol = progesterone related side effects --> fluid retention, constipation
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12
Q

LH antagonists

A 
Goserelin = hypothalamic stimulator of continuous LH release --> decrease net LH release 
Leuprolide = hypothalamic stimulator of continuous LH release --> decrease net LH release
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13
Q

TK inhibitors

A

Crizotinib - anti-ALK –> nausea, vomiting, diarrhea
Dasatinib - inhibits several TKs
Erlotinib - anti-EGFR –> diarrhea, rash
Gefitinib - anti-EGFR –> diarrhea, rash
Imatinib - anti-Bcr-Abl –> fluid retention, myelosuppression, rare cardiac
Nilotinib - inhibits several TKs
Sorafenib + Sunitinib - inhibits several TKs, raf, VEGF –> rash, diarrhea, hypertension, hand foot syndrome, clotting/bleeding

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14
Q

Anti-emetic therapy

A 
Aprepitant
Dexamethasone(steroid)
Dolasetron
Granisetron
Ondansetron
Palonosetron (LA)
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