Chemo

Question 1

Traztuzumab

Answer 1

Her2 over-expressing cancers (also T-DM1)

Question 2

Rituximab

Answer 2

CD20 expressing B cell malignancies

Question 3

Panitumumab

Answer 3

EGFR-driven cancers of GI tract, Head and Neck

Question 4

VEGFR inhibitors

Answer 4

Renal Cell carcinoma

Question 5

Aromatase inhibtors

Answer 5

Estrogen-driven malignancies

Question 6

Enzalutamide

Answer 6

PRostate

Question 7

Proteasome inhibitors for ___

Answer 7

plasma cell dyscrasias (myeloma)

Question 8

lenalidomide

Answer 8

hematologic malignancies

Question 9

ibrutinib

Answer 9

CLL and other B cell malignancies

Question 10

what cancers are considered curable

Answer 10

Acute Lymphocytic Leukemia (especially pediatric)
Some pediatric Sarcomas*
Germ Cell Tumors*
Aggressive and Intermediate Lymphomas
Acute Myeloid Leukemia (in young persons)

Question 11

FAS-mediated pathway goes through what caspase

Answer 11

Caspase 8 –> 3

Question 12

Cisplatin

Answer 12

non-classical alkylator, platinum complex
Inorganic complex
Germ cell tumors, bladder cancer

Question 13

Carboplatin

Answer 13

Non-classical Alkylator, platinum complex
Inorganic complex
Epithelial malignancies, second-line treatment
of lymphomas

Question 14

Cyclophosphamide

Answer 14

Alkylator, nitrogen mustard
Small molecule
Breast cancer, lymphomas,
immunosuppression, stem cell mobilization

Question 15

Doxorubicin

Answer 15

Topoisomerase inhibitor
Small molecule
Breast cancer, lymphomas

Question 16

5-FU

Answer 16

Antimetabolite, pyrimidine analog
Small molecule
GI cancers

Question 17

Ibrutinib

Answer 17

t Signal Transduction inhibitor, TKI
small molecule
B-cell malignancies, especially CLL

Question 18

Imatinib

Answer 18

Signal Transduction inhibitor, TKI
Small molecule
CML, GIST, Ph+ ALL

Question 19

Leuprolide

Answer 19

Signal Transduction inhibitor, Receptor
super-agonist
Peptide
PRostate and breast cancers

Question 20

Nivolumab

Answer 20

Immune checkpoint inhibitor, blocking antibody
Monoclonal antibody
Melanoma, Lung cancer, Renal Cell
Carcinoma

Question 21

Paclitaxel

Answer 21

Anti-tubulin
Small molecule
Epithelial malignancies, especially Breast and
Ovarian

Question 22

Rituximab

Answer 22

Immune therapy, antibody painting
Monoclonal ab
CD20 expressing B-cell malignancies

Question 23

Tamoxifen

Answer 23

Signal Transduction inhibitor, Receptor antagonist
small molecule
breast cancer

Question 24

Trastuzumab

Answer 24

Signal Transduction inhibitor, Receptor antagonist
small molecule
Her-2 over-expressing breast and upper GI cancers

Question 25

Anastrozole

Answer 25

Signal Transduction inhibitor, ligand reduction
small molecule
breast cancer

Question 26

bendamustine

Answer 26

alkylator, nitrogen mustard
small molecule
lymphomas

Question 27

Bortezomib

Answer 27

proteasome inhibitor
small molecule
multiple myeloma, mantle cell lymphoma, waldenstroms

Question 28

Crizotinib

Answer 28

Signal Transduction inhibitor, TKI
small molecule
Lung cancers with ALK or ROS1 activation, cmet
overexpressing thyroid cancer

Question 29

Cytarabine arabinoside

Answer 29

Antimetabolite, purine analog
small molecule
AML, second-line lymphoma

Question 30

Enzalutamide

Answer 30

Signal Transduction inhibitor, Receptor antagonist
small molecule
Prostate

Question 31

Etoposide

Answer 31

Topoisomerase inhibitor
small molecule
Germ cell tumors, Lymphoma

Question 32

Gemcitabine

Answer 32

Antimetabolite, pyrimdine analog
small molecule
Pancreas cancer, Bladder cancer, widely used in second-line setting

Question 33

Methotrexate

Answer 33

Antimetabolite
Small molecule
Many cancers

Question 34

Panitumumab

Answer 34

Signal transduction inhibitor, Receptor antagonist
Mab
EGFR driven cancers of aerodigestive tract

Question 35

Pazopanib

Answer 35

signal transduction inhibitor, TKI
small molecule
renal cell cacinoma

Question 36

temazolamide

Answer 36

non-classical alkylator
small molecule
brain cancer

Question 37

bleomycin side effect

Answer 37

pulmonary fibrosis