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Errthing > chemo > Flashcards

chemo Flashcards

1
Q

MOA: 5-FU

A

pyrimidine analogue

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2
Q

MOA: alemtuzumab

A

targets CD52

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3
Q

MOA: axitinib

A

TKI

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4
Q

MOA: azathioprine

A

purine analogue

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5
Q

MOA: bevacizumab

A

VEGF-A inhibitor

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6
Q

MOA: bleomycin

A

binds DNA (causing strand breaks? - exact action unknown)

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7
Q

MOA: bortezomib

A

protease inhibitor

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8
Q

MOA: brentuximab

A

targets CD30

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9
Q

MOA: busulfan

A

alkylating agent

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10
Q

MOA: capecitabine

A

prodrug for 5-FU (pyrimidine analogue)

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11
Q

MOA: cabazitaxel

A

taxane (microtubule stabilizer)

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12
Q

MOA: carboplatin

A

cross-links DNA

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13
Q

MOA: carmustine

A

alkylating agent (notrosourea)

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14
Q

MOA: cetuximab

A

EGFR inhibitor

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15
Q

MOA: cisplatin

A

cross-links DNA

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16
Q

MOA: cobimetinib

A

MEK inhibitor

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17
Q

MOA: crizotinib

A

inhibits ALK and ROS1

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18
Q

MOA: cyclophosphamide

A

alkylating agent (nitrogen mustard)

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19
Q

MOA: cytrarabine / ara-c

A

pyrimidine analogue

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20
Q

MOA: dabrafenib

A

BRAF inhibitor

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21
Q

MOA: dacarbazine

A

alkylating agent

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22
Q

MOA: dasatinib

A

Bcr-Abl TKI

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23
Q

MOA: docetaxel

A

taxane (microtubule stabilizer)

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24
Q

MOA: doxorubicin

A

DNA intercalation

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25
Q

MOA: epirubicin

A

DNA intercalation

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26
Q

MOA: erlotinib

A

EGFR inhibitor

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27
Q

MOA: etanercept

A

inhibits TNF-alpha

28
Q

MOA: etoposide

A

topoisomerase inhibitor

29
Q

MOA: everolimus

A

mTOR inhibitor

30
Q

MOA: fludarabine

A

purine analogue

31
Q

MOA: gefitinib

A

EGFR inhibitor

32
Q

MOA: gemcitabine

A

pyrimidine analogue

33
Q

MOA: idelalisib

A

PI3K inhibitor

34
Q

MOA: ifosfamide

A

alkylating agent (nitrogen mustard)

35
Q

MOA: imatinib

A

Bcr-Abl TKI

36
Q

MOA: infliximab

A

inhibits TNF-alpha

37
Q

MOA: ipilimumab

A

targets CTLA-4

38
Q

MOA: irinotecan

A

topoisomerase inhibitor

39
Q

MOA: lenalidomide

A

derivative of thalidomide, mechanism unknown

40
Q

MOA: leucovorin / folinic acid

A

inhibits thymidylate synthase

41
Q

MOA: lomustine

A

alkylating agent (notrosourea)

42
Q

MOA: melphalan

A

alkylating agent (nitrogen mustard)

43
Q

MOA: mercaptopurine

A

purine analogue

44
Q

MOA: methotrexate

A

inhibits dihydrofolate reductase

45
Q

MOA: mitomycin

A

cross-links DNA

46
Q

MOA: nivolumab

A

PD1 inhibitor

47
Q

MOA: oxaliplatin

A

cross-links DNA

48
Q

MOA: paclitaxel

A

taxane (microtubule stabilizer)

49
Q

MOA: panitumumab

A

EGFR inhibitor

50
Q

MOA: pazopanib

A

multikinase TKI

51
Q

MOA: pembrolizumab

A

PD1 inhibitor

52
Q

MOA: pemetrexed

A

inhibits thymidylate synthase and dihydrofolate reductase

53
Q

MOA: pertuzumab

A

targets HER2

54
Q

MOA: rituximab

A

targets CD20

55
Q

MOA: sirolimus

A

mTOR inhibitor

56
Q

MOA: sorafenib

A

multikinase TKI

57
Q

MOA: sunitinib

A

multikinase TKI

58
Q

MOA: tacrolimus

A

calcineurin inhibitor

59
Q

MOA: temozolomide

A

alkylating agent

60
Q

MOA: temsirolimus

A

mTOR inhibitor

61
Q

MOA: topotecan

A

topoisomerase inhibitor

62
Q

MOA: trametinib

A

MEK inhibitor

63
Q

MOA: trastuzumab

A

targets HER2

64
Q

MOA: vemurafenib

A

BRAF inhibitor

65
Q

MOA: vinblastine

A

disrupts microtubules (vinca alkaloid)

66
Q

MOA: vincristine

A

disrupts microtubules (vinca alkaloid)

Errthing (12 decks)

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