chemical mediators in innate and adaptive immunity

Question 1

IL-1

Answer 1

Inflammation, endothelial cell activation, fever, IL6 production

Question 2

IL2

Answer 2

Proliferation & differentiation of T cells

Question 3

IL3

Answer 3

Maturation of hematopoietic lineages, macrophage differentiation

Question 4

IL4

Answer 4

TH2 differentiation, B cell proliferation & differentiation, IgG1, IgE isotypes

Question 5

IL5

Answer 5

Plasma cell differentiation, IgA isotype, eosinophil activation

Question 6

IL6

Answer 6

Fever, acute phase response, plasma cell differentiation, Th17 differentiation

Question 7

IL7

Answer 7

B & T cell development, Memory T cells

Question 8

IL10

Answer 8

B-1 proliferation, inhibits macrophages

Question 9

IL12

Answer 9

NK cell activation, TH1 differentiation

Question 10

IL13

Answer 10

B cell differentiation, IgE isotype, macrophage alternate activation

Question 11

IL15

Answer 11

Proliferation of memory CD8+ T cells and NK cells

Question 12

IL17

Answer 12

Increased cytokine and chemokine production by macrophages and endothelial cells

Question 13

TNFα

Answer 13

Inflammation, endothelial cell activation, fever, FDC differentiation, cachexia

Question 14

TGFβ

Answer 14

Treg & Th17 differentiation, B cell differentiation, IgG2b, IgA, inhibits macrophages

Question 15

IFNγ

Answer 15

Macrophage activation, TH1 differentiation, B cell differentiation, IgG2a, IgG3 isotypes

Question 16

IFNα

Answer 16

Inhibits viral replication, increases MHC Class I expression, activates NK cells

Question 17

IFNβ

Answer 17

Inhibits viral replication, activates NK cells

Question 18

GCSF/MCSF/GMCSF

Answer 18

Granulocyte/monocyte differentiation, stem cell recruitment

Question 19

Histamine

Answer 19

Vasodilation/vascular permeability, endothelial cell activation

Question 20

Prostacyclin

Answer 20

Vasodilation

Question 21

Thromboxane

Answer 21

Vasoconstriction

Question 22

Prostaglandin E2 (PGE2)

Answer 22

Pain, central nervous system mediator of fever

Question 23

Leukotrienes

Answer 23

Vascular permeability, bronchoconstriction

Question 24

Lymphotoxin (LT)

Answer 24

FDC differentiation

Question 25

Complement

Answer 25

Opsonization, chemotactic, membrane attack

Question 26

Bradykinin

Answer 26

Pain, endothelium-dependent vasodilation and permeability

Question 27

CXCL8 (IL8)

Answer 27

Major chemotactic factor of neutrophils

Question 28

CCL2 (MCP-1)

Answer 28

Macrophage recruitment to sites of inflammation

Question 29

CCL3 (MIP-1α)

Answer 29

T cell recruitment; major HIV-suppressive factor

Question 30

CCL5 (RANTES)

Answer 30

Monocyte, memory T and eosinophil recruitment

Question 31

CCL19 (MIP3β)

Answer 31

Naïve B & T cell recruitment to secondary lymphoid tissues

Question 32

CCL21 (SLC)

Answer 32

Naïve B & T cell recruitment to secondary lymphoid tissues

Question 33

CCL11 (Eotaxin)

Answer 33

Eosinophil recruitment

Question 34

CCL18

Answer 34

Naïve T cell recruitment by mature DC

Question 35

CCL25

Answer 35

Effector T cell recruitment to gut epithelium

Question 36

CXCL13

Answer 36

B cell recruitment to primary follicle

Question 37

MAC

Answer 37

membrane attack complex

Question 38

C3b

Answer 38

tags microbe for phagocytosis

Question 39

C5a

Answer 39

chemotaxis

Question 40

C3a

Answer 40

activation of macrophages

Question 41

Prostaglandin I2 (PGI2)

Answer 41

Vasodilation

Question 42

C3b

Answer 42

opsonization

Question 43

lipoxin

Answer 43

anti-inflammatory