Chapter 9 the luteal phase Flashcards
primary secretory product of CL
P4
What controls the ability of CL to produce adequate concentrations of P4
of luteal cells and CL vascularity
why does CL’s ability to produce adequate P4 depend on CL vascularity
CL needs high blood flow to deliver precursors from gen circulation for P4 and delivery of P4 to systemic circulation
Purpose of P4
decrease GnRH pulse frequency and decreases myometrial tone (stimulates contraction in mare)
Affects of positive feedback of P4
uterine gland secretions aids in sustained embryo development prior to attachment
and
development of mammary gland during pregnancy
first step of P4 synthesis
cholesterol transported to luteal cell by lipoproteins
second step of P4 synthesis
LH binds receptors (during step 1)
third step of P4 synthesis
LH binding activate G-protein, and activates adenylate cyclase
fourth step of P4 synthesis
Adenylate cyclase promotes conversion of ATP to cAMP
fifth step of P4 synthesis
activation of protein kinases
sixth step of P4 synthesis
mitochondrial enzymes convert CHOL to pregnenalone
7th step of P4 synthesis
pregnenalone leave mitochondria and immediately converted to P4
what causes a new follicular phase
luteolysis
what was the CL lifespan in a contralateral uterectomy
normal 15-17 days
what was the CL lifespan in an ipsilateral uterectomy
35 days
